{"id":"W4401869986","doi":"10.1093/cid/ciae437","title":"PUNCH CD3-OLS: A Phase 3 Prospective Observational Cohort Study to Evaluate the Safety and Efficacy of Fecal Microbiota, Live-jslm (REBYOTA) in Adults With Recurrent <i>Clostridioides difficile</i> Infection","year":2024,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Infectious Diseases Centre; University of British Columbia","funders":"National Center for Advancing Translational Sciences; Ferring Pharmaceuticals","keywords":"Clostridioides; Medicine; Fecal bacteriotherapy; Observational study; Feces; Prospective cohort study; Cohort study; Internal medicine; Clostridium difficile; Cohort; Microbiology; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002836197,0.0007585464,0.000987887,0.0002045685,0.0008457276,0.000872009,0.0005700855,0.0008587553,0.002034824],"category_scores_gemma":[0.001606557,0.0005027046,0.001168127,0.0003282399,0.0005690047,0.0005971996,0.0004973974,0.001357994,0.0004634731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007376412,"about_ca_system_score_gemma":0.002308642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002451274,"about_ca_topic_score_gemma":0.006963661,"domain_scores_codex":[0.9991413,0.0003639687,0.00005071157,0.00018457,0.0001249429,0.0001344082],"domain_scores_gemma":[0.9982577,0.0001935662,0.0005949767,0.0002028769,0.0001969691,0.0005538832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.4334238,0.02961632,0.4680444,0.001050348,0.004263157,0.0004273894,0.0005929833,0.0005298178,0.01572169,0.0002099112,0.004164068,0.04195601],"study_design_scores_gemma":[0.1420729,0.29973,0.5430179,0.0001697041,0.003648788,0.0009902566,0.0006195679,0.001257032,0.002843006,0.0002818589,0.005266375,0.000102624],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969138,0.0006093007,0.0002544218,0.0000867807,0.00002984674,0.0006707194,0.001028354,0.00001885163,0.0003879548],"genre_scores_gemma":[0.9942947,0.0004138621,0.001312366,0.0005875725,0.0000655571,0.001008379,0.001631029,0.00001255638,0.0006739906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002836197,"threshold_uncertainty_score":0.01499945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04398693655452299,"score_gpt":0.3945612074704465,"score_spread":0.3505742709159235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}