{"id":"W4401875014","doi":"10.1016/s2152-2650(24)00611-6","title":"Tolerability of Asciminib vs Investigator-Selected (IS) Tyrosine Kinase Inhibitors (TKIs) in the Phase 3 ASC4FIRST Study in Newly Diagnosed Patients With Chronic Myeloid Leukemia in Chronic Phase (CML-CP)","year":2024,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Tolerability; Myeloid leukemia; Tyrosine kinase; Internal medicine; Oncology; Adverse effect; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001542385,0.0008297327,0.001377697,0.0002058662,0.0002677339,0.0008617669,0.0004424611,0.0007240715,0.003536325],"category_scores_gemma":[0.001187138,0.0003152099,0.001763555,0.0003179198,0.0004553658,0.0009444061,0.0002404635,0.002352586,0.0004639881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006975257,"about_ca_system_score_gemma":0.0007525298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008650573,"about_ca_topic_score_gemma":0.002501385,"domain_scores_codex":[0.9995406,0.0002426886,0.00002290974,0.0000631607,0.00003128521,0.0000993915],"domain_scores_gemma":[0.9990902,0.0002308905,0.0002261357,0.00006654853,0.00005068794,0.0003354794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9183796,0.007256985,0.01278358,0.0003077355,0.001551838,0.0001250828,0.0001210253,0.001838567,0.01046419,0.0001262804,0.002625661,0.0444194],"study_design_scores_gemma":[0.3118649,0.5614417,0.1124201,0.00006369044,0.002393268,0.0003916473,0.0002048147,0.003400788,0.004086737,0.0003845138,0.003276256,0.0000716356],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959073,0.001674005,0.0001512997,0.000218718,0.00007523009,0.0001386491,0.0008935486,0.00003395299,0.0009072651],"genre_scores_gemma":[0.9970924,0.0005983757,0.0001459763,0.0002518613,0.0001267695,0.0001310735,0.001001095,0.00001184691,0.0006405868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003536325,"threshold_uncertainty_score":0.01183015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02644281757805242,"score_gpt":0.334612103758361,"score_spread":0.3081692861803086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}