{"id":"W4401875245","doi":"10.1016/j.ekir.2024.08.020","title":"Open-Label Phase 1/2 Study of Daratumumab-Based Desensitization Before Kidney Transplantation","year":2024,"lang":"en","type":"article","venue":"Kidney International Reports","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Pharmaceuticals; Junior League of Toronto; Assistance publique-Hôpitaux de Paris; Assistance Publique - Hôpitaux de Paris","keywords":"Daratumumab; Medicine; Internal medicine; Antibody; Adverse effect; Kidney transplantation; Desensitization (medicine); Human leukocyte antigen; Transplantation; Immunology; Monoclonal antibody; Gastroenterology; Oncology; Antigen; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002085583,0.0001775805,0.000266413,0.0002959112,0.0000618674,0.0001081478,0.0001094386,0.00006258311,0.0003085517],"category_scores_gemma":[0.0001673693,0.0001463804,0.00007232932,0.0002694548,0.00002871908,0.0003045912,0.00001694748,0.0001126929,0.00001671371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001095134,"about_ca_system_score_gemma":0.0004905219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001748084,"about_ca_topic_score_gemma":0.00001895706,"domain_scores_codex":[0.9981354,0.00003521493,0.0006555542,0.0003987028,0.0006450918,0.0001299638],"domain_scores_gemma":[0.9989738,0.00004487014,0.0001802375,0.0002388809,0.0002745599,0.0002876623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.01294378,0.06593165,0.5553029,0.008826677,0.01329875,0.1510762,0.01915838,0.0008033736,0.0670732,0.0101232,0.02549786,0.06996405],"study_design_scores_gemma":[0.2536941,0.03040933,0.2228392,0.03366347,0.01343596,0.02976435,0.001856395,0.1225385,0.1940099,0.005124234,0.08960855,0.003055888],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680445,0.00004411395,0.007126611,0.002987772,0.002298569,0.001887142,0.0004841007,0.0001666511,0.01696053],"genre_scores_gemma":[0.9923707,0.00002385621,0.001223616,0.0006845215,0.00008457592,0.00006341707,0.003866058,0.00003130123,0.001651911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3324637,"threshold_uncertainty_score":0.596922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03873036867379025,"score_gpt":0.3859670746891408,"score_spread":0.3472367060153506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}