{"id":"W4401875585","doi":"10.1158/0008-5472.can-23-3890","title":"<i>PTEN</i> Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Biotechnology and Biological Sciences Research Council; Imperial Experimental Cancer Medicine Centre; Ligue Contre le Cancer; Ovarian Cancer Action; China Scholarship Council; National Institute for Health and Care Research; Cancéropôle Lyon Auvergne-Rhône-Alpes; NIHR Imperial Biomedical Research Centre; Cancer Research UK; Imperial College London; Cancer Research Institute","keywords":"PTEN; Cancer research; PI3K/AKT/mTOR pathway; Biology; Tumor microenvironment; Immune system; Ovarian carcinoma; Macrophage; Ovarian cancer; Cancer; Immunology; Signal transduction; Cell biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007187102,0.00005375965,0.00008684868,0.0002589856,0.0000959289,0.0002273287,0.00005108451,0.0001085234,0.0007728349],"category_scores_gemma":[0.00009816154,0.00006276859,0.00008250007,0.0001597248,0.0001162621,0.0001013738,0.0001056915,0.0001501841,0.0001483697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001491485,"about_ca_system_score_gemma":0.00008872351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005226985,"about_ca_topic_score_gemma":0.0005868218,"domain_scores_codex":[0.9999634,0.000004774467,0.000003111009,0.000006378581,0.00001151682,0.00001072458],"domain_scores_gemma":[0.9999347,0.000009051968,0.00002301622,0.000003963853,0.000008120743,0.00002114838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007151456,0.00004309625,0.04405693,0.00004564539,0.0000119812,0.0003508377,0.00008819902,0.0001998506,0.9490283,0.00008978177,0.0001741949,0.005196086],"study_design_scores_gemma":[0.00003467555,0.0005813793,0.7266684,0.000009208309,0.0000311215,0.0019392,0.0003959858,0.003274117,0.2642094,0.0001410533,0.00270471,0.00001068853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993029,0.0001729565,0.0001861803,0.00001284179,0.00000230616,0.000003119557,0.00005356166,0.00001255055,0.0002535959],"genre_scores_gemma":[0.9994341,0.00009943855,0.0001333249,0.00001129383,0.000002664397,0.000004916782,0.00007071263,0.000002885998,0.0002406336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007728349,"threshold_uncertainty_score":0.002585411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03107225189263349,"score_gpt":0.3300347971313376,"score_spread":0.2989625452387041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}