{"id":"W4401875816","doi":"10.1016/s2152-2650(24)01421-6","title":"MPN-274 Avapritinib in Patients With Advanced Systemic Mastocytosis (AdvSM): Efficacy and Safety Analysis From the Phase 2 PATHFINDER Study With 3-Year Follow-up","year":2024,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Medicine; Systemic mastocytosis; Pathfinder; Internal medicine; Dermatology; Oncology; Library science; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006891821,0.0004624888,0.001122007,0.0001872672,0.0002617524,0.00008879932,0.0004053261,0.0003501794,0.0003971235],"category_scores_gemma":[0.0001455472,0.0002791121,0.0002187644,0.0008747127,0.0004875098,0.000137321,0.0001845977,0.0005040489,0.0001659928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003035973,"about_ca_system_score_gemma":0.0003360028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003736402,"about_ca_topic_score_gemma":0.0006856989,"domain_scores_codex":[0.9963377,0.0006562609,0.001144865,0.001160583,0.0001672649,0.0005333243],"domain_scores_gemma":[0.9970074,0.001686186,0.0002436271,0.000844925,0.0001198072,0.00009808214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02084398,0.001743536,0.6155429,0.00005737029,0.004385562,0.0001749295,0.001582308,0.00005404694,0.0003104082,0.0001296499,0.0004627572,0.3547125],"study_design_scores_gemma":[0.04179312,0.003006605,0.9455013,0.0002981018,0.001591241,0.00001084288,0.0009716413,0.00005483941,0.00003880771,0.000009450184,0.006298535,0.0004255536],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995275,0.002134507,0.0001076484,0.00008392377,0.0004837505,0.001204064,0.0003307452,0.0001160267,0.0002643554],"genre_scores_gemma":[0.998189,0.0001164167,0.00008957168,0.0001539584,0.00007279026,0.00008485421,0.0005454143,0.00005774515,0.00069026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3542869,"threshold_uncertainty_score":0.9999661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128851723779347,"score_gpt":0.2666581885978581,"score_spread":0.2553696713600646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}