{"id":"W4401875816","doi":"10.1016/s2152-2650(24)01421-6","title":"MPN-274 Avapritinib in Patients With Advanced Systemic Mastocytosis (AdvSM): Efficacy and Safety Analysis From the Phase 2 PATHFINDER Study With 3-Year Follow-up","year":2024,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Medicine; Systemic mastocytosis; Pathfinder; Internal medicine; Dermatology; Oncology; Library science; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001465193,0.0007921703,0.001585914,0.000359493,0.0002241394,0.0008396655,0.0005941627,0.0006148226,0.001670769],"category_scores_gemma":[0.0006774815,0.000322538,0.001546402,0.0003194916,0.0004478825,0.0006842017,0.0002800318,0.001808824,0.0004970533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007354211,"about_ca_system_score_gemma":0.0007490234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005154037,"about_ca_topic_score_gemma":0.001807166,"domain_scores_codex":[0.9996116,0.0001424617,0.00002088205,0.00007166876,0.00007253564,0.00008092707],"domain_scores_gemma":[0.9996046,0.00009575496,0.0001039248,0.0000370392,0.00003399582,0.0001247007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.387433,0.01413643,0.04127038,0.002337983,0.007781575,0.0007911937,0.0002828367,0.01009322,0.06266673,0.0006753203,0.01263992,0.4598915],"study_design_scores_gemma":[0.4130058,0.3754343,0.1650511,0.0001775574,0.004712716,0.002992062,0.0002113662,0.00815946,0.01276515,0.001047242,0.01629474,0.0001484301],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890032,0.00691257,0.0004690449,0.0004028132,0.00008169362,0.0003415485,0.001062318,0.0001292437,0.00159749],"genre_scores_gemma":[0.9930099,0.002539666,0.0006910454,0.0004623183,0.00008582677,0.0002335275,0.001969961,0.00002176818,0.0009861037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001670769,"threshold_uncertainty_score":0.007748723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128851723779347,"score_gpt":0.2666581885978581,"score_spread":0.2553696713600646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}