{"id":"W4401875886","doi":"10.1016/s2152-2650(24)01345-4","title":"MDS-157 Overall Survival (OS), Clinical Benefit, and Durable Red Blood Cell (RBC) Transfusion Independence (TI) With Imetelstat in the IMerge Phase 3 Trial of RBC-Transfusion Dependent (TD) Lower-Risk Myelodysplastic Syndromes (LR-MDS)","year":2024,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Myelodysplastic syndromes; Red blood cell; Blood transfusion; Clinical trial; Red Blood Cell Transfusion; Internal medicine; Oncology; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001617349,0.0009381943,0.001279368,0.0002961081,0.0002583909,0.0009566793,0.0005710582,0.0006790765,0.003788967],"category_scores_gemma":[0.000952395,0.0002606105,0.001726844,0.0002955009,0.0005463489,0.0006548876,0.0003954219,0.00277681,0.0004073129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006163953,"about_ca_system_score_gemma":0.0007161272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005050727,"about_ca_topic_score_gemma":0.002315875,"domain_scores_codex":[0.9995829,0.0002378908,0.00002204276,0.00004736298,0.00003310495,0.00007665287],"domain_scores_gemma":[0.9995196,0.0001303444,0.0001083751,0.00004040053,0.00001857252,0.0001826889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.880038,0.006658664,0.01103214,0.0007199355,0.003468387,0.000107226,0.0001217652,0.003766348,0.008285807,0.0008573242,0.006325873,0.07861851],"study_design_scores_gemma":[0.6457483,0.2696838,0.05975617,0.0002035487,0.004542775,0.0003761126,0.0001570094,0.004609437,0.00428945,0.002116001,0.008449985,0.00006738891],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910678,0.003518448,0.000248942,0.0006345437,0.0001569971,0.0002603815,0.001316541,0.00005721109,0.002739077],"genre_scores_gemma":[0.9924979,0.001238441,0.000509321,0.0005787099,0.0002230802,0.0004389169,0.002301927,0.00001501884,0.002196807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003788967,"threshold_uncertainty_score":0.0126754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03013156918352923,"score_gpt":0.3401590380652639,"score_spread":0.3100274688817347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}