{"id":"W4401875977","doi":"10.1158/0008-5472.can-23-4024","title":"Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Biology; Stem cell; Context (archaeology); Cancer research; Genetic heterogeneity; Gene; Genetics; Computational biology; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001831765,0.0005078522,0.0003392496,0.0003903796,0.0002258985,0.0003982524,0.0002294732,0.000319185,0.00164119],"category_scores_gemma":[0.0002917172,0.0001603712,0.0003375433,0.0002399114,0.000207981,0.0001364778,0.0005016754,0.0005168311,0.0003390449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004921287,"about_ca_system_score_gemma":0.0003207726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001557379,"about_ca_topic_score_gemma":0.00414583,"domain_scores_codex":[0.9997529,0.00002045537,0.00002798958,0.00006186944,0.00008888441,0.0000477842],"domain_scores_gemma":[0.9998597,0.000041918,0.00003615047,0.00001661551,0.00002416091,0.00002142451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003310359,0.00002672313,0.0006023709,0.00004331515,0.00001103714,0.00007597776,0.00001992289,0.0005290784,0.9953204,0.000143294,0.0001002485,0.003094524],"study_design_scores_gemma":[0.00001135534,0.0003626834,0.0113136,0.00001359927,0.00005970855,0.0004047837,0.00006865377,0.004683401,0.9792236,0.0001798543,0.003657282,0.00002149348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98001,0.0005902335,0.0115334,0.00009610455,0.0000198385,0.0001515783,0.002753208,0.0006154784,0.004230151],"genre_scores_gemma":[0.9857355,0.0007002637,0.006972018,0.0001405073,0.000003496752,0.0001471274,0.002865658,0.0001633003,0.003271987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00164119,"threshold_uncertainty_score":0.005490303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08017606560292605,"score_gpt":0.383302278504516,"score_spread":0.3031262129015899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}