{"id":"W4401876091","doi":"10.1016/s2152-2650(24)01267-9","title":"CLL-186 Interim Results From ASSURE: A Phase 3b Safety Study of Acalabrutinib in Patients With Chronic Lymphocytic Leukemia","year":2024,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"CancerCare Manitoba","funders":"","keywords":"Medicine; Chronic lymphocytic leukemia; Interim; Interim analysis; Leukemia; Oncology; Internal medicine; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002849482,0.0008798615,0.001627598,0.0004393608,0.0005311068,0.0014446,0.0006344265,0.0008633269,0.004308399],"category_scores_gemma":[0.001762072,0.0003870704,0.001799948,0.0004259607,0.0006335425,0.0007392394,0.0003949412,0.00273599,0.001206531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001087762,"about_ca_system_score_gemma":0.001682462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001015968,"about_ca_topic_score_gemma":0.003314777,"domain_scores_codex":[0.999091,0.0005439969,0.00003721897,0.00008146957,0.0001049628,0.0001413839],"domain_scores_gemma":[0.9989987,0.0002809346,0.000228591,0.0000977966,0.00009726837,0.0002967634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5583386,0.01469211,0.0274208,0.001713704,0.0048876,0.0003907767,0.0004746762,0.00538774,0.03937117,0.001862586,0.04569899,0.2997614],"study_design_scores_gemma":[0.5834557,0.2675129,0.07448398,0.0002291232,0.00299206,0.001535003,0.0002213867,0.003909459,0.01159521,0.001971082,0.05197203,0.0001220771],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9614134,0.01171838,0.001935047,0.001709043,0.0002519,0.001478879,0.008000312,0.000644186,0.0128489],"genre_scores_gemma":[0.9782074,0.002963672,0.002594838,0.002343293,0.0003191856,0.001451618,0.00854411,0.0001077692,0.003468176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004308399,"threshold_uncertainty_score":0.01506966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03645167953478672,"score_gpt":0.3677568805810247,"score_spread":0.331305201046238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}