{"id":"W4401878183","doi":"10.1016/s2152-2650(24)00662-1","title":"Efficacy and Safety Is Maintained in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria Receiving Pegcetacoplan for Up to 3 Years","year":2024,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"","keywords":"Paroxysmal nocturnal hemoglobinuria; Medicine; Nocturnal; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005473137,0.0003220568,0.0006120885,0.0001622459,0.0001311415,0.00007945421,0.0003212114,0.0002916826,0.0003699975],"category_scores_gemma":[0.0006207844,0.0002747087,0.0001646028,0.0002582452,0.0001959526,0.0001120888,0.0002005708,0.0002171144,0.0003024955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005243135,"about_ca_system_score_gemma":0.0004473011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000654996,"about_ca_topic_score_gemma":0.0000824801,"domain_scores_codex":[0.9971658,0.0002652256,0.001017915,0.0008405382,0.00009581383,0.0006147057],"domain_scores_gemma":[0.9976991,0.001495505,0.0001339078,0.0004078483,0.0001150371,0.000148572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01451813,0.0002933992,0.3900455,0.0003574488,0.0006883764,0.00009534421,0.001411495,0.00001495866,0.0004733013,0.0009231463,0.04691679,0.5442621],"study_design_scores_gemma":[0.01144595,0.0007518635,0.9532015,0.0006677526,0.00009843108,0.00003294657,0.0001275906,0.00005461746,0.0001135302,0.0001042551,0.03303624,0.0003653331],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955103,0.0004868591,0.0001298825,0.0004006832,0.001559194,0.001279897,0.0003489264,0.000130836,0.0001533745],"genre_scores_gemma":[0.9974183,0.00002521244,0.0003041766,0.0007786957,0.0001584011,0.0001066761,0.0002507897,0.0000521368,0.0009056201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.563156,"threshold_uncertainty_score":0.9999705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01458068107565661,"score_gpt":0.2952509919852363,"score_spread":0.2806703109095797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}