{"id":"W4401878297","doi":"10.1016/s2152-2650(24)00620-7","title":"Dose-Optimization Study of 3 Starting Doses of Ponatinib: Long-Term Results From the OPTIC Trial","year":2024,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Ponatinib; Term (time); Oncology; Internal medicine; Dasatinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002353673,0.001457868,0.003939046,0.0003733741,0.0004822895,0.001878135,0.001061742,0.001436936,0.002763347],"category_scores_gemma":[0.003264598,0.0004905657,0.003623866,0.0005784329,0.001272127,0.001649734,0.0005312675,0.004191771,0.0009105136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001818098,"about_ca_system_score_gemma":0.00161732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001425396,"about_ca_topic_score_gemma":0.002717451,"domain_scores_codex":[0.9985488,0.0005906543,0.00007356532,0.0003011933,0.0001753233,0.0003103842],"domain_scores_gemma":[0.9982609,0.0004316294,0.0005054211,0.0002780936,0.00009534523,0.0004286186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9070213,0.00788024,0.00515644,0.0003727418,0.003538039,0.00009456097,0.00017877,0.003058982,0.004742716,0.0002427396,0.002960439,0.0647529],"study_design_scores_gemma":[0.6736876,0.2493507,0.05532739,0.0001010839,0.005648355,0.000479235,0.0002169544,0.004489864,0.002648282,0.001525808,0.006322308,0.0002024572],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921775,0.003452125,0.0004620848,0.0004766743,0.0001053653,0.0002801741,0.0009297322,0.00008313783,0.00203313],"genre_scores_gemma":[0.9939621,0.001090371,0.0007933478,0.0007040483,0.0001452876,0.0003801654,0.001641801,0.00005481227,0.001228024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003939046,"threshold_uncertainty_score":0.01319134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0779670394684194,"score_gpt":0.395783041813826,"score_spread":0.3178160023454066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}