{"id":"W4401878556","doi":"10.1016/s2152-2650(24)00388-4","title":"Overall Survival (OS), Clinical Benefit, and Durable Red Blood Cell (RBC) Transfusion Independence (TI) With Imetelstat in the IMerge Phase 3 Trial of RBC-Transfusion Dependent (TD) Lower-Risk Myelodysplastic Syndromes (LR-MDS)","year":2024,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Myelodysplastic syndromes; Internal medicine; Blood transfusion; Clinical trial; Red blood cell; Oncology; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002154344,0.001171437,0.001450533,0.0003278468,0.0002720677,0.001055411,0.0006752685,0.0008012597,0.003040204],"category_scores_gemma":[0.001173817,0.0002875348,0.001954376,0.0003805569,0.0006910461,0.0008944728,0.0004404536,0.003424383,0.0003442457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006862375,"about_ca_system_score_gemma":0.0007000247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005853153,"about_ca_topic_score_gemma":0.002399571,"domain_scores_codex":[0.9994548,0.0003192507,0.00002515639,0.00006263129,0.00003745521,0.0001007537],"domain_scores_gemma":[0.9993665,0.0001870883,0.0001374239,0.00005045288,0.00001982082,0.000238769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8842843,0.006607038,0.01119956,0.0007181843,0.003635758,0.0001051924,0.0001275197,0.004331893,0.00661813,0.0007160441,0.006367495,0.07528896],"study_design_scores_gemma":[0.6089932,0.3102979,0.05809039,0.0001821759,0.005338235,0.0003983024,0.0001664875,0.004901135,0.003237895,0.002193544,0.006121438,0.00007934401],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911442,0.004317251,0.0002493122,0.0007101341,0.0001569258,0.0002138225,0.001155591,0.00004769813,0.00200524],"genre_scores_gemma":[0.9928791,0.001567111,0.0004438016,0.0006834628,0.0002543256,0.0004103533,0.002063816,0.00001502779,0.00168293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003040204,"threshold_uncertainty_score":0.01139343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03014526474343783,"score_gpt":0.3402547526484732,"score_spread":0.3101094879050354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}