{"id":"W4401879340","doi":"10.1158/2326-6066.cir-24-0463","title":"Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity","year":2024,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; Ludwig Center at Harvard; Fondation pour la Recherche Médicale; Glenn Foundation for Medical Research; Canadian Institutes of Health Research; American Cancer Society","keywords":"Immune system; Immunotherapy; CD8; Immunology; Cytotoxic T cell; Antigen; T cell; Cancer; Medicine; Immunity; Cancer research; Biology; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001392836,0.0002322166,0.0004574133,0.0007126825,0.0004346806,0.00006424075,0.0004154606,0.0003992822,0.009370799],"category_scores_gemma":[0.0002001212,0.0002150926,0.0002121209,0.0008601206,0.001082324,0.000294715,0.0001643314,0.00220761,0.002476354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005021681,"about_ca_system_score_gemma":0.0003267345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001474161,"about_ca_topic_score_gemma":0.00007174315,"domain_scores_codex":[0.996887,0.001185258,0.0005768654,0.0004675731,0.0001173715,0.0007659493],"domain_scores_gemma":[0.9979307,0.0008636109,0.0001346706,0.0005075664,0.000537671,0.00002580408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006157645,0.0002282834,0.0002541937,0.0000517873,0.0006239141,0.00003533829,0.0004817542,0.000006383393,0.9313143,0.0008669246,0.06073141,0.004789954],"study_design_scores_gemma":[0.0009379236,0.0004695806,0.007446667,0.0002323689,0.00003064771,0.00007847419,0.001083138,0.00002016617,0.6288851,0.0001024238,0.3605185,0.0001949404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9065656,0.06943396,0.00005687977,0.0004518473,0.01596582,0.0004977899,0.00004246491,0.0002158697,0.00676976],"genre_scores_gemma":[0.9669539,0.005552711,0.000004945767,0.00004365918,0.00006627305,0.0001204813,0.0001603178,0.00004165596,0.02705607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3024291,"threshold_uncertainty_score":0.9983003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05197326157117774,"score_gpt":0.345738669116768,"score_spread":0.2937654075455903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}