{"id":"W4401879452","doi":"10.1101/2024.08.23.609450","title":"TUMOR-INFILTRATING NOCICEPTOR NEURONS PROMOTE IMMUNOSUPPRESSION","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer, Stress, Anesthesia, and Immune Response","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Nociceptor; Infiltration (HVAC); Cancer research; Cytotoxic T cell; Nociception; CD8; Immune system; Medicine; Neuroscience; Immunology; Chemistry; Biology; Internal medicine; Receptor; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000133108,0.0003576096,0.0002089941,0.0002207471,0.0001197594,0.0003334408,0.00009742418,0.0002503316,0.004733827],"category_scores_gemma":[0.00007088327,0.0001168486,0.00022236,0.0001109875,0.0002127198,0.0001754969,0.000263638,0.0008627389,0.00113553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001914559,"about_ca_system_score_gemma":0.0001969359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002253016,"about_ca_topic_score_gemma":0.0003329952,"domain_scores_codex":[0.9999017,0.00001202238,0.000007260185,0.00001790208,0.00003197408,0.00002921084],"domain_scores_gemma":[0.9999495,0.000005726658,0.00001207861,0.000005739781,0.000008051344,0.00001889701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001386375,0.00002744243,0.0001636159,0.00004793848,0.000004974885,0.00003588933,0.00001217161,0.00006538599,0.9968387,0.0001809731,0.0002036378,0.002280614],"study_design_scores_gemma":[0.00001894896,0.0001293251,0.002719847,0.000008972375,0.000008477467,0.0001424403,0.00002286344,0.0004786794,0.9909043,0.0001323477,0.005431328,0.000002612851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788958,0.00411867,0.006801434,0.0007500091,0.0002596693,0.00006205647,0.002014063,0.0003758662,0.006722407],"genre_scores_gemma":[0.9732323,0.002253363,0.003951495,0.0002400404,0.00005627261,0.00005389085,0.001790052,0.0001288923,0.01829381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004733827,"threshold_uncertainty_score":0.01583624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183942021713676,"score_gpt":0.2401896495047771,"score_spread":0.2283502292876403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}