{"id":"W4401885706","doi":"10.22541/au.172467563.34999747/v1","title":"Genotoxicity evaluation of gene therapies: highlights from IWGT 2022","year":2024,"lang":"en","type":"preprint","venue":"","topic":"Biomedical Ethics and Regulation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Genotoxicity; Transparency (behavior); Session (web analytics); Computational biology; Medicine; Bioinformatics; Computer science; Biology; World Wide Web; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00133923,0.0001936882,0.0004257574,0.0001604003,0.00002824778,0.00001818813,0.0001139493,0.0008674897,0.003614452],"category_scores_gemma":[0.00004674823,0.0001271003,0.000205445,0.0001419172,0.0002611444,0.00001098988,0.000261103,0.0008190785,0.00004913192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001642899,"about_ca_system_score_gemma":0.0008103139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008180251,"about_ca_topic_score_gemma":0.00007923604,"domain_scores_codex":[0.9972253,0.0001361574,0.000466764,0.0004616822,0.001587771,0.0001222841],"domain_scores_gemma":[0.9986272,0.00006673309,0.0001610552,0.0005239266,0.0005157192,0.0001052942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0003513692,0.001021076,0.000148398,0.003087619,0.004652789,0.00003288847,0.01036919,0.0003882047,0.6856859,0.0373678,0.009953631,0.2469411],"study_design_scores_gemma":[0.002021149,0.0002007895,0.01496827,0.001413012,0.003053261,0.000005684343,0.0002274083,0.1181624,0.1667582,0.6847132,0.0080065,0.0004701439],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9196791,0.02152712,0.003217581,0.03732136,0.003126276,0.001821252,0.0002318939,0.0001749266,0.01290051],"genre_scores_gemma":[0.9932869,0.0006745995,0.002877441,0.0002972211,0.0008085049,0.00004930822,0.0008870848,0.00002923566,0.001089725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6473454,"threshold_uncertainty_score":0.9972964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06416774744837984,"score_gpt":0.3531692462693032,"score_spread":0.2890014988209234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}