{"id":"W4401885706","doi":"10.22541/au.172467563.34999747/v1","title":"Genotoxicity evaluation of gene therapies: highlights from IWGT 2022","year":2024,"lang":"en","type":"preprint","venue":"","topic":"Biomedical Ethics and Regulation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Genotoxicity; Transparency (behavior); Session (web analytics); Computational biology; Medicine; Bioinformatics; Computer science; Biology; World Wide Web; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04404382,0.001660255,0.001129279,0.001423177,0.001894311,0.009064507,0.002120317,0.01327354,0.009836699],"category_scores_gemma":[0.02546442,0.0006058568,0.001613329,0.001660177,0.002705924,0.005406546,0.007683247,0.01318127,0.004721003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007323052,"about_ca_system_score_gemma":0.01359463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004807037,"about_ca_topic_score_gemma":0.006550392,"domain_scores_codex":[0.9840354,0.006250535,0.0008608037,0.001067558,0.006245491,0.001540121],"domain_scores_gemma":[0.9759942,0.01241625,0.001038802,0.0008132427,0.007025948,0.002711489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005342791,0.0002245765,0.0004891164,0.002804975,0.0000753934,0.001989581,0.0033322,0.001914631,0.006946907,0.05177855,0.6833988,0.246511],"study_design_scores_gemma":[0.00001920691,0.00008768001,0.0004792664,0.001299187,0.00001432071,0.0003799084,0.001027945,0.0001359295,0.001788281,0.01209284,0.9826367,0.00003878655],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.006340563,0.2113232,0.01341313,0.6458651,0.0658447,0.0003037624,0.0009285345,0.0002435805,0.05573747],"genre_scores_gemma":[0.08662154,0.3077644,0.03855959,0.3101286,0.08272292,0.000960089,0.003353718,0.001335553,0.1685537],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.04404382,"threshold_uncertainty_score":0.2329288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06416774744837984,"score_gpt":0.3531692462693032,"score_spread":0.2890014988209234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}