{"id":"W4401889573","doi":"10.3390/cancers16172949","title":"Genome-Wide CRISPR Screen Identifies KEAP1 Perturbation as a Vulnerability of ARID1A-Deficient Cells","year":2024,"lang":"en","type":"article","venue":"Cancers","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Terry Fox Research Institute; University of British Columbia","funders":"Terry Fox Research Institute","keywords":"CRISPR; ARID1A; Biology; Genome; Computational biology; Vulnerability (computing); Genetics; Computer science; Computer security; Gene; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001237175,0.0002798682,0.000335834,0.0002530944,0.000196955,0.0003343427,0.0002431454,0.0004081797,0.001962497],"category_scores_gemma":[0.0001393827,0.0001206634,0.0002810626,0.0001837467,0.0002021119,0.0001042109,0.0003309825,0.0005073163,0.0005089762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001787402,"about_ca_system_score_gemma":0.0001558943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005367891,"about_ca_topic_score_gemma":0.0008879102,"domain_scores_codex":[0.9998426,0.00001539381,0.00001906296,0.00004419139,0.00005087223,0.00002778889],"domain_scores_gemma":[0.9998654,0.00003652672,0.00003066161,0.00002050545,0.000009306104,0.00003756721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003973265,0.00001144023,0.0002376607,0.00002321802,0.000007313779,0.000106956,0.000008449492,0.00007063408,0.9987667,0.00006108377,0.00005036579,0.0006165261],"study_design_scores_gemma":[0.000008972896,0.00013559,0.007858546,0.00000653443,0.00002662436,0.0008453613,0.00004478181,0.001213223,0.9868631,0.00007669354,0.002910841,0.000009767204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867429,0.0008065838,0.006994005,0.0001493654,0.00004698356,0.00004538148,0.002726017,0.0003556974,0.002133064],"genre_scores_gemma":[0.9922109,0.0004454139,0.003149873,0.00008648093,0.000004727946,0.00004347365,0.001371151,0.0000521463,0.002635859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001962497,"threshold_uncertainty_score":0.006565154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01146092468525375,"score_gpt":0.2726560861738603,"score_spread":0.2611951614886066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}