{"id":"W4401892746","doi":"10.1007/s43657-024-00187-5","title":"Deficiency of Gut-Enriched Lipase H Promotes Gut Aging and Reduces Lifespan in Drosophila","year":2024,"lang":"en","type":"article","venue":"Phenomics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Key Research and Development Program of China; Institute of Genetics; Fudan University; National Natural Science Foundation of China","keywords":"Biology; Gene knockdown; STAT protein; Cell biology; Janus kinase; Immune system; Signal transduction; STAT3; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001116417,0.0003357223,0.0002150458,0.0005623662,0.0001525535,0.0002913315,0.0002066832,0.0002718953,0.001267411],"category_scores_gemma":[0.0001115695,0.0002016422,0.0002133342,0.0002011457,0.0004115469,0.0001641598,0.0002689901,0.0004417906,0.0002598716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000546038,"about_ca_system_score_gemma":0.0002241546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00143759,"about_ca_topic_score_gemma":0.00326106,"domain_scores_codex":[0.999913,0.00001152219,0.00001086996,0.00002671544,0.00001959648,0.00001834812],"domain_scores_gemma":[0.9998105,0.00002938122,0.0000700476,0.00001649326,0.000009030685,0.00006449901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002404779,0.0000148909,0.0004876325,0.00001996155,0.000007346029,0.00004539869,0.00000922223,0.0001009606,0.9978294,0.0001279128,0.00005123997,0.00106542],"study_design_scores_gemma":[0.00004638751,0.0001511985,0.01489952,0.000008770186,0.00002738952,0.0001674463,0.00006667435,0.00161494,0.9812084,0.0001055614,0.001691094,0.00001262364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954726,0.0006343108,0.00183626,0.0001303209,0.00002208915,0.00001357825,0.001009727,0.000110059,0.0007711365],"genre_scores_gemma":[0.992125,0.0005834451,0.002544816,0.00008753116,0.000008036199,0.00002684628,0.0005212178,0.00006180874,0.004041352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00143759,"threshold_uncertainty_score":0.004239857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0120713886505742,"score_gpt":0.2472684350662889,"score_spread":0.2351970464157147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}