{"id":"W4401893651","doi":"10.1101/2024.08.21.24312360","title":"Widespread environment-specific causal effects detected in the UK Biobank","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"","keywords":"Mendelian randomization; Biobank; Causal inference; Causal model; Socioeconomic status; Interaction; Structural equation modeling; Blood pressure; Medicine; Internal medicine; Psychology; Environmental health; Econometrics; Chemistry; Biology; Bioinformatics; Statistics; Mathematics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01447449,0.0003543946,0.0008561458,0.001174927,0.0007077702,0.00136786,0.0010637,0.001293298,0.004553697],"category_scores_gemma":[0.05528129,0.0005555588,0.0008603788,0.003020386,0.001244216,0.0009261479,0.001877266,0.0007028198,0.0002886995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00182639,"about_ca_system_score_gemma":0.001521541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.05476168,"about_ca_topic_score_gemma":0.04209658,"domain_scores_codex":[0.9773355,0.01540213,0.001661968,0.003887811,0.001028962,0.0006836663],"domain_scores_gemma":[0.9330952,0.04239293,0.0121404,0.009640313,0.002147173,0.0005840738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001052147,0.00005202594,0.9598925,0.0004308052,0.001294612,0.001183778,0.00128501,0.01175941,0.001167218,0.003907088,0.002471804,0.01550359],"study_design_scores_gemma":[0.0003030766,0.0002459262,0.9519074,0.0003254413,0.001053543,0.001222102,0.0008080893,0.02797778,0.001116744,0.008066757,0.006851065,0.0001222082],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974591,0.001889595,0.01465255,0.001172469,0.00004899541,0.0001057854,0.006115164,0.0001447118,0.001279734],"genre_scores_gemma":[0.995259,0.000193806,0.003131249,0.0001598201,0.00001090354,0.00006472259,0.001000387,0.00001097991,0.0001690635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05476168,"threshold_uncertainty_score":0.1088859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418377666620074,"score_gpt":0.2513294230209094,"score_spread":0.2371456463547086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}