{"id":"W4401894068","doi":"10.3390/cancers16172953","title":"Sialylation Inhibition Can Partially Revert Acquired Resistance to Enzalutamide in Prostate Cancer Cells","year":2024,"lang":"en","type":"article","venue":"Cancers","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council Canada; Medical Research Council; Newcastle University; Prostate Cancer UK","keywords":"Enzalutamide; Prostate cancer; Cancer research; Cancer; Cancer cell; Medicine; Internal medicine; Androgen receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008312139,0.0003369657,0.000370512,0.000131596,0.00009823299,0.0003200065,0.0002612638,0.0002329128,0.0008682772],"category_scores_gemma":[0.00008993283,0.0001224867,0.0002889716,0.0002004274,0.0001115375,0.0001400014,0.0001779527,0.0005736724,0.0002766483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002153868,"about_ca_system_score_gemma":0.0003004364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002137601,"about_ca_topic_score_gemma":0.002381787,"domain_scores_codex":[0.9998881,0.0000185861,0.0000132191,0.00001623951,0.00003285785,0.00003094119],"domain_scores_gemma":[0.9999483,0.000009971764,0.00001088877,0.00001026211,0.000007568095,0.00001312258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001627206,0.0001117968,0.0001742537,0.00003804611,0.00001329507,0.00005338235,0.00001993248,0.0002472234,0.9968498,0.0000797161,0.00008436458,0.002165476],"study_design_scores_gemma":[0.00003672219,0.001313472,0.003395686,0.000005506656,0.00002567765,0.0002567283,0.00002850095,0.001736145,0.9899791,0.00002958056,0.00318574,0.000007120911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946149,0.001881669,0.001118199,0.00008271873,0.00004126156,0.00004023346,0.0003798941,0.0001084517,0.001732647],"genre_scores_gemma":[0.9944459,0.001436464,0.001218494,0.00006159263,0.000007563306,0.00003108938,0.0009530609,0.00002025079,0.001825552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002137601,"threshold_uncertainty_score":0.004250348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01203348475280525,"score_gpt":0.2898753199305484,"score_spread":0.2778418351777432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}