{"id":"W4401901977","doi":"10.1101/2024.08.26.609787","title":"Mining Yeast Diversity Unveils Novel Targets for Improved Heterologous Laccase Production in <i>Saccharomyces cerevisiae</i>","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Enzyme-mediated dye degradation","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Saccharomyces cerevisiae; Heterologous; Yeast; Laccase; Saccharomyces; Diversity (politics); Production (economics); Biology; Biotechnology; Genetics; Gene; Biochemistry; Enzyme; Political science; Economics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000785695,0.000506279,0.0005186169,0.0001094812,0.0002746618,0.0002340878,0.000547584,0.0005821303,0.00002335352],"category_scores_gemma":[0.0003598949,0.0002921842,0.0001965644,0.0006397622,0.00007684733,0.0002147207,0.001167396,0.0006378879,0.0000268509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000248819,"about_ca_system_score_gemma":0.0000806703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002907411,"about_ca_topic_score_gemma":0.0001854609,"domain_scores_codex":[0.997173,0.00008923991,0.0005205578,0.001355923,0.0002623144,0.0005989663],"domain_scores_gemma":[0.9987571,0.0001093616,0.0003730252,0.0002764999,0.0003025522,0.0001814762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006920576,0.0001782905,0.004029707,0.0003046506,0.0000627248,0.00001435299,0.00002173235,0.00003337863,0.9945743,0.00002988245,0.000624483,0.00005730704],"study_design_scores_gemma":[0.001293586,0.0005039155,0.236072,0.001252651,0.0004002452,2.186796e-7,0.00006437939,0.002987289,0.7446397,0.0000424094,0.01010366,0.002639913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925227,0.001006295,0.0000328908,0.001518968,0.002029308,0.001429917,0.001042101,0.0004152668,0.00000262078],"genre_scores_gemma":[0.9966077,0.0001272783,0.001680846,0.0001809503,0.001106065,0.0002610587,0.00001260054,0.00001397561,0.000009570212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2499346,"threshold_uncertainty_score":0.999953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02109388148646763,"score_gpt":0.2091165584277205,"score_spread":0.1880226769412529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}