{"id":"W4401905203","doi":"10.1007/978-1-0716-4108-8_6","title":"CRISPR-Mediated Viral Gene Knockout to Investigate Viral Evasion of Antiviral Innate Immunity","year":2024,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"CRISPR; Biology; Innate immune system; Gene; Acquired immune system; Genome editing; Immune system; Herpes simplex virus; Virology; Evasion (ethics); Computational biology; Virus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005945902,0.0006747619,0.0005972213,0.0006144415,0.0004078722,0.0007619743,0.0007790182,0.0009531571,0.002684973],"category_scores_gemma":[0.0002978284,0.0004265568,0.0006149287,0.0003072599,0.0006954104,0.0005537482,0.0004762512,0.002284234,0.001071856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001012499,"about_ca_system_score_gemma":0.0005157794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001035152,"about_ca_topic_score_gemma":0.001594045,"domain_scores_codex":[0.9992926,0.0001116683,0.00007418636,0.0001430331,0.0002358974,0.0001426272],"domain_scores_gemma":[0.9997155,0.0000854585,0.0000708288,0.00005006866,0.00002492084,0.00005327159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004902078,0.00002653864,0.00006597907,0.00002691284,0.000006757095,0.00002418178,0.0000105856,0.0001162912,0.9983803,0.0006319038,0.00006740601,0.0005940247],"study_design_scores_gemma":[0.00001690698,0.00009618891,0.000694883,0.000007119514,0.00001565964,0.0001495938,0.00002033101,0.001923661,0.9940569,0.0001753199,0.002835404,0.000007995132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8333324,0.003394064,0.140771,0.0009881452,0.0005556905,0.0005367557,0.005204576,0.001635821,0.01358148],"genre_scores_gemma":[0.9511599,0.00116953,0.03478744,0.000259231,0.00002735184,0.0002739137,0.001588666,0.0002836366,0.01045043],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002684973,"threshold_uncertainty_score":0.008982182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01541367251747511,"score_gpt":0.4124966534879486,"score_spread":0.3970829809704735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}