{"id":"W4401905249","doi":"10.21873/cgp.20470","title":"PIK3CA Mutated Colorectal Cancers Without KRAS, NRAS and BRAF Mutations Possess Common and Potentially Targetable Mutations in Epigenetic Modifiers and DNA Damage Response Genes","year":2024,"lang":"en","type":"article","venue":"Cancer Genomics & Proteomics","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Essar Steel Algoma (Canada); Sault Area Hospital","funders":"","keywords":"KRAS; Neuroblastoma RAS viral oncogene homolog; Colorectal cancer; Cancer research; Epigenetics; Mutation; Gene; Biology; Cancer; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002341825,0.0002160165,0.0003305121,0.0009536216,0.000280416,0.0004755469,0.0001580713,0.0002022071,0.00259554],"category_scores_gemma":[0.0006161815,0.0001238874,0.0002425985,0.001166751,0.000213466,0.0001910799,0.0003938854,0.0002155943,0.0003880707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002843794,"about_ca_system_score_gemma":0.0003134885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001480479,"about_ca_topic_score_gemma":0.003014195,"domain_scores_codex":[0.999779,0.00001764217,0.00002532605,0.00007078832,0.00005996857,0.00004734946],"domain_scores_gemma":[0.999337,0.00008642916,0.0003506201,0.00007256746,0.00006216882,0.00009122177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005950849,0.00004199721,0.9278067,0.0002378501,0.0002198854,0.001498897,0.0000826313,0.0002449684,0.04287903,0.0001334171,0.0007040641,0.02555552],"study_design_scores_gemma":[0.0000128305,0.0001302259,0.982093,0.00001885882,0.0001302837,0.009034552,0.00008937555,0.0002191541,0.00596871,0.0001938898,0.002101972,0.000007158589],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953113,0.00137007,0.0005322167,0.00005345522,0.000006399287,0.00001197089,0.001669371,0.00007135561,0.0009738783],"genre_scores_gemma":[0.9972466,0.0003854502,0.0006073246,0.00002609095,0.000009788252,0.000007027953,0.001491235,0.000008071508,0.0002183563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00259554,"threshold_uncertainty_score":0.008682966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01423350406227582,"score_gpt":0.2947545339009395,"score_spread":0.2805210298386637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}