{"id":"W4401905249","doi":"10.21873/cgp.20470","title":"PIK3CA Mutated Colorectal Cancers Without KRAS, NRAS and BRAF Mutations Possess Common and Potentially Targetable Mutations in Epigenetic Modifiers and DNA Damage Response Genes","year":2024,"lang":"en","type":"article","venue":"Cancer Genomics & Proteomics","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Essar Steel Algoma (Canada); Sault Area Hospital","funders":"","keywords":"KRAS; Neuroblastoma RAS viral oncogene homolog; Colorectal cancer; Cancer research; Epigenetics; Mutation; Gene; Biology; Cancer; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002436265,0.0003238239,0.0005090625,0.0002697617,0.0003069452,0.000172698,0.00006666371,0.0001261889,0.00001727029],"category_scores_gemma":[0.00004196755,0.0003118459,0.00005000756,0.000336627,0.000450463,0.0001562954,0.0001037803,0.0002576864,0.000001220557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009077546,"about_ca_system_score_gemma":0.001075039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003034587,"about_ca_topic_score_gemma":0.006402631,"domain_scores_codex":[0.9983803,0.00009079331,0.0003851128,0.0006042065,0.0001454708,0.0003941363],"domain_scores_gemma":[0.9993107,0.0001313338,0.00008722682,0.000165085,0.00009957005,0.0002060457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01673981,0.0004285561,0.2449126,0.001791841,0.002893502,0.001245049,0.04456782,0.01482006,0.5983318,0.000511887,0.0002304623,0.07352654],"study_design_scores_gemma":[0.01433867,0.002943148,0.7828099,0.001132757,0.002549933,0.0006271843,0.007479891,0.1150289,0.06450364,0.002720066,0.00390963,0.001956308],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.973167,0.02274559,0.0002700107,0.001254422,0.0002402632,0.001816725,0.0003296703,0.00007006928,0.000106266],"genre_scores_gemma":[0.9892544,0.006431093,0.003034453,0.0001369348,0.00007956888,0.0006571826,0.00007699927,0.00006631724,0.0002630264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5378973,"threshold_uncertainty_score":0.9999334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01423350406227582,"score_gpt":0.2947545339009395,"score_spread":0.2805210298386637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}