{"id":"W4401908914","doi":"10.1182/blood.2024024405","title":"Genetic engineering of transfusable platelets with mRNA-lipid nanoparticles is compatible with blood banking practices","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; iCo Therapeutics (Canada); University of British Columbia","funders":"","keywords":"Platelet; Hemostasis; Transfection; Platelet activation; Medicine; Messenger RNA; Immunology; Platelet transfusion; Chemistry; Internal medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001798101,0.0002628085,0.0001430113,0.0001420394,0.0001411837,0.0003356236,0.000172624,0.0003389492,0.0007023267],"category_scores_gemma":[0.0002428331,0.0001170092,0.00018456,0.0001337933,0.0002063965,0.0001615322,0.0001985051,0.0004264745,0.0003524114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002997089,"about_ca_system_score_gemma":0.0002529252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004578348,"about_ca_topic_score_gemma":0.0006340423,"domain_scores_codex":[0.9997662,0.00003665873,0.00002055035,0.00004583299,0.0001035379,0.00002730223],"domain_scores_gemma":[0.9998655,0.00002765174,0.00004985055,0.0000162931,0.00002820067,0.0000123817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001129372,0.00000833375,0.0000624893,0.00001887907,0.000001744932,0.00003417176,0.00001135506,0.00008528097,0.998207,0.0001485052,0.00003683538,0.001374126],"study_design_scores_gemma":[0.000004418681,0.00009189921,0.0004740183,0.000004001948,0.000008893116,0.0001185474,0.000009696161,0.0009625537,0.9951147,0.00004783494,0.00315972,0.000003805064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9045478,0.001168347,0.08611117,0.0004447026,0.0001764918,0.0002061915,0.0003195544,0.0005120669,0.006513762],"genre_scores_gemma":[0.95739,0.000862863,0.03625794,0.0001422431,0.00002206506,0.0001310018,0.0003932706,0.0001165837,0.004684143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007023267,"threshold_uncertainty_score":0.002349496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009386797886174142,"score_gpt":0.2201426853534381,"score_spread":0.2107558874672639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}