{"id":"W4401911711","doi":"10.3390/ijms25179262","title":"Endothelial Cell-Derived Soluble CD200 Determines the Ability of Immune Cells to Cross the Blood–Brain Barrier","year":2024,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Alberta","funders":"University Hospital Foundation; Reta Lila Weston Institute of Neurological Studies, UCL Queen Square Institute of Neurology,University College London; Canadian Institutes of Health Research; Multiple Sclerosis Society; University of Alberta","keywords":"Experimental autoimmune encephalomyelitis; Blood–brain barrier; Immune system; Cell biology; Endothelial stem cell; Biology; Cell adhesion; Cell; Antibody; Immunology; Central nervous system; Chemistry; Neuroscience; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000742852,0.0001661256,0.0001483284,0.0001892888,0.0001010545,0.0004082918,0.0001284409,0.0002544313,0.0008549026],"category_scores_gemma":[0.0001172956,0.00007236011,0.0001020637,0.0001114094,0.0001261668,0.0002376351,0.0001299728,0.0003580907,0.0002627481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002920734,"about_ca_system_score_gemma":0.0001127165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005417849,"about_ca_topic_score_gemma":0.0005393667,"domain_scores_codex":[0.9999245,0.00001260893,0.000006454577,0.00001725886,0.00002164855,0.00001749547],"domain_scores_gemma":[0.9999214,0.000009479355,0.00002682583,0.000005402178,0.00001386884,0.00002298505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002728473,0.000006257947,0.000224925,0.000009340672,0.000002024015,0.0000358781,0.000007364415,0.00001639452,0.9988721,0.0001002552,0.00001554753,0.000682606],"study_design_scores_gemma":[0.000006605033,0.00009741301,0.009154839,0.000005340331,0.00001343019,0.0004644747,0.00003013688,0.0007459878,0.987039,0.0001111418,0.002327811,0.000003892304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946982,0.001688247,0.002174064,0.00005137753,0.00001123465,0.000007085032,0.0001333798,0.00003642448,0.001199965],"genre_scores_gemma":[0.9966475,0.0007387316,0.001093987,0.00002824575,0.000006289526,0.000005187843,0.0002295893,0.000006953762,0.001243514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008549026,"threshold_uncertainty_score":0.00285995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02006442738403254,"score_gpt":0.2977410962883467,"score_spread":0.2776766689043141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}