{"id":"W4401914444","doi":"10.1186/s12964-024-01782-9","title":"Inhibition of bromodomain and extra-terminal proteins targets constitutively active NFκB and STAT signaling in lymphoma and influences the expression of the antiapoptotic proteins BCL2A1 and c-MYC","year":2024,"lang":"en","type":"article","venue":"Cell Communication and Signaling","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutschen Konsortium für Translationale Krebsforschung; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Genomics; Genome Canada; McGill University; Bayer; Genentech; Deutsche Krebshilfe; Pfizer; Deutsches Krebsforschungszentrum; Bristol-Myers Squibb","keywords":"Bromodomain; Signal transduction; Transcription factor; Cancer research; Cell biology; CREB; Biology; Enhancer; stat; JAK-STAT signaling pathway; STAT protein; Chemistry; Epigenetics; STAT3; Biochemistry; Gene; Tyrosine kinase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001508002,0.0002343949,0.0002063814,0.000178159,0.0001006176,0.0002629225,0.000192818,0.0001753253,0.0007999643],"category_scores_gemma":[0.00008851165,0.0001087587,0.0002178915,0.0001435176,0.0001861718,0.0001752058,0.0001228132,0.0005223415,0.000192891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002628416,"about_ca_system_score_gemma":0.0002007433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005062005,"about_ca_topic_score_gemma":0.0008828082,"domain_scores_codex":[0.9998542,0.00002406075,0.00001198438,0.00002060085,0.00004211219,0.00004703055],"domain_scores_gemma":[0.9999433,0.00001034993,0.00001338246,0.000006903826,0.000005475911,0.00002066579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002110134,0.00005377264,0.0001435908,0.000023387,0.000005184071,0.00002256139,0.000008630026,0.00005897468,0.998403,0.00008343296,0.00002047417,0.0009659016],"study_design_scores_gemma":[0.00005285459,0.0005462458,0.003498679,0.000003747249,0.00002295449,0.0002101968,0.00002242756,0.001135174,0.9925352,0.0000426447,0.001926263,0.000003451782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958543,0.001991069,0.0009553992,0.00005155683,0.00001844152,0.00001031232,0.00010074,0.00003663374,0.0009816741],"genre_scores_gemma":[0.99766,0.0006331882,0.0004534925,0.00002450812,0.000004476572,0.00001384957,0.0001523776,0.000005542176,0.001052484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007999643,"threshold_uncertainty_score":0.002676129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01134098474902353,"score_gpt":0.2392268281026665,"score_spread":0.227885843353643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}