{"id":"W4401914474","doi":"10.1080/19420862.2024.2394229","title":"Developability considerations for bispecific and multispecific antibodies","year":2024,"lang":"en","type":"review","venue":"mAbs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"AbCellera (Canada)","funders":"","keywords":"Bispecific antibody; Computer science; Immunogenicity; Adept; Computational biology; Antibody; Biology; Monoclonal antibody; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003094869,0.0003845238,0.001418569,0.000269038,0.0002090515,0.0001212671,0.00006965424,0.000230806,0.0002853177],"category_scores_gemma":[0.0003494043,0.0002511978,0.0004345605,0.0001912538,0.0002731069,0.00003445704,0.0001404479,0.0004571782,0.0003193175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008732658,"about_ca_system_score_gemma":0.0004581663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001934009,"about_ca_topic_score_gemma":0.00003124487,"domain_scores_codex":[0.9981692,0.00006147075,0.0005681432,0.0006155494,0.0002412516,0.0003443123],"domain_scores_gemma":[0.9983825,0.000886824,0.00007025761,0.0003054678,0.0001760162,0.0001789418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004037072,0.000081623,0.00005142436,0.1014196,0.000477491,0.0001590032,0.0001073266,1.48718e-8,0.000005896609,0.01154478,0.04847062,0.8376419],"study_design_scores_gemma":[0.0001788992,0.00008558672,0.00009825185,0.006099179,0.0007532545,0.0004626292,0.0000205261,0.00001257659,0.000002911704,0.001638697,0.9903997,0.0002477881],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005954742,0.9945896,0.00001785376,0.0009735666,0.0003541236,0.001768224,0.0005519114,0.00007686015,0.001608317],"genre_scores_gemma":[0.00004827634,0.9845544,0.003469477,0.00005431827,0.0004789059,0.0002573734,0.0002852712,0.00005915909,0.01079278],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9419291,"threshold_uncertainty_score":0.999994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2307935514832632,"score_gpt":0.4519229980909855,"score_spread":0.2211294466077223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}