{"id":"W4401914474","doi":"10.1080/19420862.2024.2394229","title":"Developability considerations for bispecific and multispecific antibodies","year":2024,"lang":"en","type":"review","venue":"mAbs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"AbCellera (Canada)","funders":"","keywords":"Bispecific antibody; Computer science; Immunogenicity; Adept; Computational biology; Antibody; Biology; Monoclonal antibody; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003436926,0.001001046,0.0009869947,0.002510468,0.0003880779,0.001578191,0.001268332,0.001686214,0.003976115],"category_scores_gemma":[0.002549794,0.0005315383,0.0009067917,0.001535713,0.0007319381,0.002300662,0.0008540148,0.00253625,0.001701441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001383393,"about_ca_system_score_gemma":0.001728731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001737221,"about_ca_topic_score_gemma":0.002178024,"domain_scores_codex":[0.9985901,0.0002865837,0.0001698017,0.0001611241,0.0006637715,0.0001287319],"domain_scores_gemma":[0.9985812,0.0007992313,0.0001852108,0.00004014964,0.0003482513,0.00004598291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001339704,0.0001704127,0.0003115365,0.02838234,0.00009718161,0.0005691043,0.0002242701,0.001831203,0.0219036,0.05003674,0.02147433,0.8748654],"study_design_scores_gemma":[0.00001659388,0.0002174766,0.0003897715,0.002580416,0.00006772373,0.001078869,0.00005579405,0.0002611741,0.007738905,0.003702589,0.9838685,0.00002216662],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001074091,0.9872646,0.002634506,0.0007309103,0.0003344714,0.00005960901,0.00006489883,0.0000245033,0.007812438],"genre_scores_gemma":[0.008120721,0.9808936,0.004790552,0.0008905982,0.0002932621,0.0001365587,0.0001697566,0.00001519048,0.004689815],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003976115,"threshold_uncertainty_score":0.01817638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2307935514832632,"score_gpt":0.4519229980909855,"score_spread":0.2211294466077223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}