{"id":"W4401915213","doi":"10.1042/bcj20240114","title":"Filamin A regulates platelet shape change and contractile force generation via phosphorylation of the myosin light chain","year":2024,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Michael Smith Health Research BC; Centre for Blood Research, University of British Columbia; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Arthritis Society; Division of Civil, Mechanical and Manufacturing Innovation; National Institutes of Health; National Science Foundation","keywords":"FLNA; Filamin; Myosin light-chain kinase; Cell biology; Phosphorylation; Platelet activation; Protein kinase C; Myosin; Platelet; Actin; Actin cytoskeleton; Cytoskeleton; Thrombin; Chemistry; Microfilament; Biology; Biochemistry; Cell; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000737907,0.0003087814,0.0001120802,0.0002345436,0.0002294678,0.000308563,0.0002336468,0.000344143,0.00110059],"category_scores_gemma":[0.00008985028,0.0001539486,0.0002478382,0.0001028902,0.0002520951,0.0001971758,0.000231559,0.0007638478,0.0003431388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004284183,"about_ca_system_score_gemma":0.0001923819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001082434,"about_ca_topic_score_gemma":0.0012831,"domain_scores_codex":[0.9998895,0.00001641813,0.000009881002,0.00001944354,0.00003289499,0.00003188465],"domain_scores_gemma":[0.9999129,0.00000824906,0.00003414272,0.000006621084,0.000008561311,0.00002963758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000163879,0.00002378708,0.0002460183,0.00001810204,0.000005596214,0.00007821881,0.000007315641,0.00004075204,0.9983505,0.0001246116,0.0000468555,0.0008944756],"study_design_scores_gemma":[0.00007634704,0.0002924627,0.03345297,0.00001233865,0.00005222368,0.0004436114,0.00008635788,0.001963521,0.9590158,0.0001629823,0.004431794,0.000009573447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914021,0.002657589,0.002874433,0.0002905368,0.0000421269,0.00003155075,0.00036438,0.00008941565,0.002247852],"genre_scores_gemma":[0.9943824,0.001356458,0.001094369,0.0001005754,0.00001406007,0.0000340561,0.0003063856,0.00001720443,0.002694416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00110059,"threshold_uncertainty_score":0.003681898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01957629106431401,"score_gpt":0.2478019912492763,"score_spread":0.2282257001849623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}