{"id":"W4401915780","doi":"10.1039/d4md00476k","title":"Pyridinyl 4-(2-oxoalkylimidazolidin-1-yl)benzenesulfonates and their hydrochloride salts as novel water soluble antimitotic prodrugs bioactivated by cytochrome P450 1A1 in breast cancer cells","year":2024,"lang":"en","type":"article","venue":"RSC Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec; Hôpital Saint-François d'Assise","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Centre Hospitalier Universitaire de Québec; Réseau Québécois de Recherche sur les Médicaments; Université Laval","keywords":"Prodrug; Chemistry; Hydrochloride; Ring (chemistry); Stereochemistry; Solubility; Combinatorial chemistry; Medicinal chemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001411801,0.0002335855,0.0002174266,0.0001017696,0.00006949002,0.0001288724,0.0001714368,0.0002181212,0.0008523587],"category_scores_gemma":[0.0001032318,0.0001256915,0.0000913539,0.0001091779,0.0001069505,0.0002132933,0.0001480447,0.0002384019,0.0003268855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000136013,"about_ca_system_score_gemma":0.0001584698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002890087,"about_ca_topic_score_gemma":0.0007046061,"domain_scores_codex":[0.9999256,0.00002297984,0.000008552762,0.00001181007,0.00001620761,0.00001478203],"domain_scores_gemma":[0.9999679,0.000003923074,0.00001292645,0.00000259846,0.00000507219,0.000007487137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002602748,0.00003788065,0.00006457064,0.0001581938,0.00000864638,0.00007699243,0.00003621353,0.0003787818,0.989527,0.0004568706,0.0002081758,0.008786559],"study_design_scores_gemma":[0.0001111408,0.001280011,0.0006033446,0.000008163501,0.00001740147,0.000175382,0.00001502038,0.001021075,0.9900158,0.00004340694,0.006700072,0.00000918439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761612,0.009524313,0.007466777,0.0002053621,0.0001129067,0.000116482,0.0002514657,0.0001827154,0.005978899],"genre_scores_gemma":[0.9880016,0.003434332,0.003582431,0.00004547674,0.00001960192,0.00005042955,0.0001883541,0.0000156514,0.004662168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008523587,"threshold_uncertainty_score":0.002851367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009242217518795035,"score_gpt":0.2229208933545978,"score_spread":0.2136786758358027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}