{"id":"W4401916101","doi":"10.1021/acs.biochem.4c00380","title":"The <i>Salmonella</i> Effector SspH2 Facilitates Spatially Selective Ubiquitination of NOD1 to Enhance Inflammatory Signaling","year":2024,"lang":"en","type":"article","venue":"Biochemistry","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Li Ka Shing Institute of Virology, University of Alberta; Government of Alberta; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation; University of Alberta","keywords":"Effector; Ubiquitin; Salmonella; NOD1; Cell biology; Chemistry; Signal transduction; Microbiology; Biology; Biochemistry; Bacteria; NOD2; Innate immune system; Genetics; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001428776,0.0002743111,0.0001977261,0.0001039351,0.0001142695,0.0002641492,0.0001237241,0.0002060322,0.001020773],"category_scores_gemma":[0.00007978896,0.0001084928,0.0002183203,0.00007986104,0.0001433419,0.000163613,0.0003316126,0.0002457502,0.0004304678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002018862,"about_ca_system_score_gemma":0.0001260434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001551141,"about_ca_topic_score_gemma":0.0003299951,"domain_scores_codex":[0.9998714,0.00002671519,0.000009887865,0.00002740789,0.00003039259,0.00003419905],"domain_scores_gemma":[0.9999353,0.000007906905,0.00001880899,0.00001008013,0.000007318099,0.00002066775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004775852,0.000008378304,0.0001987708,0.00001446358,0.000002331905,0.00003297015,0.00000244174,0.00003945145,0.9992719,0.00003609013,0.00002328468,0.0003220629],"study_design_scores_gemma":[0.000008466517,0.00008401732,0.003804402,0.000001957269,0.000003547359,0.0002538902,0.0000121253,0.0007359333,0.9939404,0.00002273806,0.001130104,0.000002610684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947609,0.0006398036,0.002718031,0.00006726011,0.00001265519,0.000008529774,0.0001396897,0.00008448038,0.00156849],"genre_scores_gemma":[0.9971506,0.000164046,0.001484338,0.00003891554,0.0000049048,0.000004807328,0.0002378416,0.00001226418,0.0009023133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001020773,"threshold_uncertainty_score":0.00341481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003808132865615205,"score_gpt":0.241284964540075,"score_spread":0.2374768316744598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}