{"id":"W4401916621","doi":"10.3390/cells13171430","title":"iPSC-Derived Cardiomyocytes as a Disease Model to Understand the Biology of Congenital Heart Defects","year":2024,"lang":"en","type":"review","venue":"Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Children's Health Research Institute; University of Nebraska Medical Center","keywords":"Induced pluripotent stem cell; Disease; Personalization; Computational biology; Genome editing; Heart disease; Biology; Neuroscience; Drug discovery; Human Induced Pluripotent Stem Cells; Embryonic stem cell; Computer science; Bioinformatics; Medicine; CRISPR; Genetics; Pathology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002567621,0.0003912722,0.0008167295,0.0001248828,0.00006233233,0.00004257852,0.0005467791,0.0003073212,0.00001626582],"category_scores_gemma":[0.00008087075,0.0002555657,0.0007627929,0.0002115143,0.0002336843,0.000001680849,0.000626554,0.0002486421,0.0002565437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005180401,"about_ca_system_score_gemma":0.0008490848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001253151,"about_ca_topic_score_gemma":0.000005151587,"domain_scores_codex":[0.9980784,0.0002564085,0.0003639447,0.0006764728,0.0002025051,0.0004222506],"domain_scores_gemma":[0.9986697,0.00006803646,0.00008433937,0.0008199221,0.00008702291,0.0002710174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007972749,0.0006288973,0.00001642616,0.09450141,0.009932462,0.0003868864,0.0005948902,0.001804844,0.5713322,0.001751198,0.1599359,0.1583177],"study_design_scores_gemma":[0.0001399509,0.0001735381,3.445923e-7,0.0008495555,0.0009305902,0.00001768377,0.00003650957,0.00007614522,0.009566626,0.0001576566,0.9876698,0.0003815661],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002942356,0.9938496,0.0002250561,0.00006891046,0.0002350531,0.001178288,0.0004704036,0.00001315997,0.001017148],"genre_scores_gemma":[0.01295067,0.9836846,0.00004845936,0.00009150204,0.0001736518,0.00009261409,0.0002526248,0.00008062074,0.002625285],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8277339,"threshold_uncertainty_score":0.9999896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05272679890733836,"score_gpt":0.3470219477079706,"score_spread":0.2942951488006322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}