{"id":"W4401923757","doi":"10.1016/j.neuropharm.2024.110132","title":"Rapid reorganization of serotonin projections and antidepressant response to 5-HT1A-biased agonist NLX-101 in fluoxetine-resistant cF1ko mice","year":2024,"lang":"en","type":"article","venue":"Neuropharmacology","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; University of Ottawa","keywords":"Fluoxetine; Agonist; Antidepressant; Serotonin; Pharmacology; Psychology; Serotonin Agonist; 5-HT receptor; Partial agonist; Psychotherapist; Neuroscience; Medicine; Receptor; Internal medicine; Hippocampus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003078352,0.0001976965,0.0002425094,0.0005273889,0.0001212042,0.00006262636,0.0002286282,0.00008192819,0.0001915986],"category_scores_gemma":[0.001222823,0.0001975296,0.0000449558,0.001467433,0.0002014193,0.000128181,0.0001397411,0.000285637,0.00004563254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004059867,"about_ca_system_score_gemma":0.0001601608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005261245,"about_ca_topic_score_gemma":0.00003058083,"domain_scores_codex":[0.9975143,0.0008654174,0.0003964015,0.0006988418,0.0001814673,0.000343569],"domain_scores_gemma":[0.9985761,0.001000513,0.00007051116,0.0001922183,0.00004614275,0.0001144926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001752526,0.000151567,0.0002663371,0.0001027734,0.000005182827,0.0003580998,0.0005442857,0.00009239189,0.9937512,0.000214217,0.001827095,0.000934306],"study_design_scores_gemma":[0.001319044,0.0005423093,0.02471827,0.00004419292,0.00002086475,0.00007772163,0.00008315567,0.001357336,0.9478822,0.00004152626,0.02369419,0.0002192102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940962,0.0002029987,0.00003789185,0.003381528,0.0006880406,0.0009290036,0.00006043798,0.0001706932,0.0004332192],"genre_scores_gemma":[0.997196,0.0002160482,0.00008989953,0.001902691,0.00004973265,0.0000729947,0.000002623611,0.00004825398,0.000421714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04586904,"threshold_uncertainty_score":0.8055022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.022740440826712,"score_gpt":0.2969318251921597,"score_spread":0.2741913843654477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}