{"id":"W4401929521","doi":"10.1016/j.cell.2024.07.052","title":"Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals","year":2024,"lang":"en","type":"article","venue":"Cell","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"Merkin Institute for Translational Research, California Institute of Technology; Coalition for Epidemic Preparedness Innovations; Wellcome Trust; University of Utah; California Institute of Technology; National Institutes of Health; Case Western Reserve University; Wellcome Leap; National Institute of Allergy and Infectious Diseases; Rockefeller University; Pfizer; Bill and Melinda Gates Foundation","keywords":"Biology; Antibody; Virology; Cross-reactivity; Mosaic; Antigen; Vaccination; Immunology; Cross reactions","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001923469,0.0005265152,0.0003194864,0.0003294208,0.000146618,0.0002057809,0.0001483156,0.0005340872,0.001752831],"category_scores_gemma":[0.0001388772,0.0001775464,0.0001799633,0.0000860813,0.0002313818,0.0002434294,0.0001581333,0.001126789,0.0004828115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002353067,"about_ca_system_score_gemma":0.0001509714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005239667,"about_ca_topic_score_gemma":0.0007610636,"domain_scores_codex":[0.9997687,0.00002884027,0.00001322949,0.00007471627,0.00003944145,0.00007504177],"domain_scores_gemma":[0.9998502,0.00003734158,0.00003098274,0.00001808616,0.00002198051,0.00004151128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003219435,0.0002812186,0.0001848776,0.00004169885,0.000005227353,0.00003043503,0.00003218957,0.00007414309,0.9976436,0.00006920163,0.0000565449,0.001258864],"study_design_scores_gemma":[0.00007503889,0.007117466,0.004340296,0.00001515679,0.00002587689,0.0002109304,0.00006444207,0.001199391,0.9849381,0.0001016148,0.00190475,0.000007015574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952199,0.0003586365,0.001352601,0.000073884,0.00006965135,0.00008364237,0.0002239488,0.00009820503,0.002519551],"genre_scores_gemma":[0.9938301,0.0003144694,0.001207278,0.00009656665,0.00003077532,0.00007494872,0.0003530002,0.00002435959,0.004068391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001752831,"threshold_uncertainty_score":0.005863786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03845818637902202,"score_gpt":0.3812170385706627,"score_spread":0.3427588521916407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}