{"id":"W4401929521","doi":"10.1016/j.cell.2024.07.052","title":"Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals","year":2024,"lang":"en","type":"article","venue":"Cell","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"Merkin Institute for Translational Research, California Institute of Technology; Coalition for Epidemic Preparedness Innovations; Wellcome Trust; University of Utah; California Institute of Technology; National Institutes of Health; Case Western Reserve University; Wellcome Leap; National Institute of Allergy and Infectious Diseases; Rockefeller University; Pfizer; Bill and Melinda Gates Foundation","keywords":"Biology; Antibody; Virology; Cross-reactivity; Mosaic; Antigen; Vaccination; Immunology; Cross reactions","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004907346,0.0001770234,0.0002664416,0.0003356418,0.0000572394,0.0001298074,0.0001502195,0.0001337089,0.0000811315],"category_scores_gemma":[0.0003290886,0.0001508347,0.00009197164,0.0007310727,0.00008106785,0.0001423255,0.00008613419,0.0003836155,0.0008324372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002273958,"about_ca_system_score_gemma":0.0004328226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005984994,"about_ca_topic_score_gemma":0.00008174206,"domain_scores_codex":[0.9983522,0.000107408,0.0002962189,0.0004510588,0.0003208498,0.0004722782],"domain_scores_gemma":[0.9990497,0.0004435655,0.00002807798,0.0003274822,0.00009231728,0.0000589003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00189478,0.0001798618,0.04249439,0.0002281513,0.00002840178,0.000870157,0.0009821438,0.000001203789,0.9508485,0.0000458645,0.0006781923,0.001748389],"study_design_scores_gemma":[0.001026952,0.0003105605,0.06596093,0.000118913,0.00002409832,0.00002709346,0.00008620547,0.0007624324,0.8550889,0.0002522047,0.07620381,0.0001379368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896501,0.004900614,0.000005418383,0.0003204275,0.000116418,0.0004393493,0.000021552,0.0001800872,0.00436602],"genre_scores_gemma":[0.9951675,0.00001444611,0.00003424337,0.003592115,0.00009634858,0.00006300036,0.0000031336,0.00004298323,0.0009862165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09575959,"threshold_uncertainty_score":0.9999455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03845818637902202,"score_gpt":0.3812170385706627,"score_spread":0.3427588521916407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}