{"id":"W4401944511","doi":"10.1016/j.gendis.2024.101402","title":"Insights into targeting LKB1 in tumorigenesis","year":2024,"lang":"en","type":"review","venue":"Genes & Diseases","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Carcinogenesis; Computational biology; Cancer research; Biology; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00006935649,0.0006708949,0.001946959,0.000566176,0.00005915729,0.00005302303,0.0002878667,0.0002880818,0.0002676141],"category_scores_gemma":[0.0001942914,0.0004898083,0.0007692116,0.0009011662,0.00009568516,0.00003953333,0.0002567035,0.0003544576,0.0005354533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005546661,"about_ca_system_score_gemma":0.001414704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008101264,"about_ca_topic_score_gemma":0.00005835494,"domain_scores_codex":[0.9972628,0.000137136,0.0008132725,0.0008949329,0.0004645891,0.0004272498],"domain_scores_gemma":[0.9987316,0.000144035,0.000158222,0.0005599828,0.00007263722,0.0003335741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002381778,0.0001178132,0.0003293902,0.05816863,0.0002358057,0.0005603434,0.0001099397,0.000002467441,0.00001675739,0.00001737087,0.004106372,0.9363113],"study_design_scores_gemma":[0.0001527115,0.000097947,0.0001887655,0.01647386,0.003815414,0.00002000755,0.0000439483,0.000006941591,0.0000251354,0.0002193492,0.9784759,0.0004799953],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001703695,0.9948828,0.000002330671,0.00003171646,0.001717785,0.001133813,0.000055267,0.0001637549,0.0003088766],"genre_scores_gemma":[0.001672043,0.9951806,0.0002287165,0.00008168428,0.00116372,0.0006638276,0.0003609528,0.0001765007,0.000471927],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9743695,"threshold_uncertainty_score":0.9997554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0326908933481497,"score_gpt":0.3518473179267934,"score_spread":0.3191564245786437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}