{"id":"W4401948749","doi":"10.7554/elife.97865.2.sa0","title":"Author response: Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross stage recognition of glutamate-rich repeats","year":2024,"lang":"en","type":"peer-review","venue":"","topic":"Malaria Research and Control","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"Biological and Environmental Research; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; French Infrastructure for Integrated Structural Biology; Wellcome Trust; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Agence Nationale de la Recherche; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source; Hospital for Sick Children; Centre National de la Recherche Scientifique; University of California, San Francisco; Canadian Institute for Advanced Research; Office of Science; Bill and Melinda Gates Foundation; Brookhaven National Laboratory; Argonne National Laboratory; U.S. Department of Energy","keywords":"Biology; Plasmodium falciparum; Monoclonal antibody; Epitope; Gametocyte; Antibody; Antigen; Population; Virology; Genetics; Malaria; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001007038,0.001059648,0.0007045158,0.0005049035,0.0008125799,0.001848737,0.0008623268,0.005228879,0.2081653],"category_scores_gemma":[0.003634893,0.0003606906,0.000590139,0.0002379507,0.0005798913,0.0006412156,0.001181985,0.003104449,0.0708895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009489042,"about_ca_system_score_gemma":0.0009649617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000580863,"about_ca_topic_score_gemma":0.001057824,"domain_scores_codex":[0.998725,0.0002382987,0.00008648486,0.0003532687,0.0003517766,0.0002451189],"domain_scores_gemma":[0.99803,0.000616376,0.0001080712,0.00008877202,0.0007292421,0.0004276091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009662615,0.0001216656,0.0006844864,0.0005548059,0.00003887322,0.0005935502,0.0001105399,0.0002093555,0.00971017,0.0007735571,0.9448676,0.0413692],"study_design_scores_gemma":[0.0001927921,0.0003443563,0.002310515,0.0001811295,0.0000282246,0.0006160092,0.0003727709,0.0004566211,0.006127228,0.0007208817,0.9886103,0.00003916536],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.02341595,0.01386127,0.008643245,0.3741893,0.32474,0.001464191,0.004826412,0.004834212,0.2440256],"genre_scores_gemma":[0.06389337,0.006399414,0.003727576,0.1587296,0.02850009,0.0005494639,0.003509865,0.0005770547,0.7341136],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.2081653,"threshold_uncertainty_score":0.6963824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06944251969128917,"score_gpt":0.4102010093051959,"score_spread":0.3407584896139067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}