{"id":"W4401948835","doi":"10.1001/jamapsychiatry.2024.2406","title":"Polygenic Risk Scores and Twin Concordance for Schizophrenia and Bipolar Disorder","year":2024,"lang":"en","type":"article","venue":"JAMA Psychiatry","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Center for Advancing Translational Sciences","keywords":"Bipolar disorder; Concordance; Schizophrenia (object-oriented programming); Twin study; Psychiatry; Psychology; Schizoaffective disorder; Clinical psychology; Medicine; Psychosis; Genetics; Heritability; Internal medicine; Mood; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001406005,0.0001777865,0.0002173646,0.0001647668,0.0001156758,0.0001131159,0.00004927018,0.00008935807,0.00007801417],"category_scores_gemma":[0.00008244965,0.0001323963,0.00008572327,0.0001783841,0.0001200468,0.00009146697,0.00004068025,0.0002331001,0.00004815904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001970411,"about_ca_system_score_gemma":0.0002402557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001508344,"about_ca_topic_score_gemma":0.0006569653,"domain_scores_codex":[0.9989523,0.00002952123,0.0001606092,0.000411294,0.0001612129,0.0002851025],"domain_scores_gemma":[0.9993393,0.0001196005,0.00002964353,0.0002311204,0.00002501736,0.0002552579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006998521,0.0001617112,0.5481855,0.0005904812,0.0005094312,0.00002823334,0.00008392137,1.818184e-7,0.0001560679,0.0261932,0.01242744,0.4046653],"study_design_scores_gemma":[0.01716107,0.001545237,0.8709372,0.0006323106,0.0004802643,0.0002563003,0.0001472863,0.002030759,0.0001181142,0.0255447,0.08080453,0.0003422028],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8094089,0.18184,0.0002518425,0.007091647,0.0003525125,0.0005997259,0.00009936131,0.0001226513,0.0002333139],"genre_scores_gemma":[0.9604556,0.004851622,0.03146984,0.0002583646,0.00076671,0.0001378897,0.0000250422,0.00008706981,0.001947859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4043231,"threshold_uncertainty_score":0.5398963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009757107459644015,"score_gpt":0.2872401900511866,"score_spread":0.2774830825915425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}