{"id":"W4401975730","doi":"10.3390/brainsci14080833","title":"Genetically Predicted Association of 91 Circulating Inflammatory Proteins with Multiple Sclerosis: A Mendelian Randomization Study","year":2024,"lang":"en","type":"article","venue":"Brain Sciences","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"ShanXi Science and Technology Department","keywords":"Mendelian randomization; Multiple sclerosis; Association (psychology); Genetics; Biology; Mendelian inheritance; Genetic association; Immunology; Medicine; Computational biology; Gene; Psychology; Single-nucleotide polymorphism; Genetic variants; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00957463,0.0008983561,0.001108899,0.001152872,0.0005975873,0.0006997245,0.0007155191,0.001017067,0.002532776],"category_scores_gemma":[0.02427235,0.0004795685,0.002090384,0.001276442,0.000686347,0.000353827,0.0005611294,0.0007595707,0.0002926239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003126596,"about_ca_system_score_gemma":0.0005574896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001916749,"about_ca_topic_score_gemma":0.0009584466,"domain_scores_codex":[0.9870839,0.00820221,0.0005748476,0.002840671,0.0009125111,0.0003858455],"domain_scores_gemma":[0.9909532,0.005528624,0.001025839,0.001960646,0.0002937113,0.0002380508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01478314,0.0006401995,0.8999296,0.0002728672,0.008682973,0.006312583,0.0008553207,0.006257553,0.01814787,0.006983874,0.001645349,0.03548857],"study_design_scores_gemma":[0.002940375,0.005127108,0.8518335,0.0001204746,0.01051832,0.01407959,0.0003304388,0.09346091,0.004957849,0.01098268,0.005399227,0.0002495298],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735883,0.0005973878,0.02413587,0.0001998462,0.00005958047,0.0001700997,0.0005235219,0.0001170043,0.0006084148],"genre_scores_gemma":[0.9876533,0.000119249,0.01136788,0.00007796886,0.00002478468,0.0001301891,0.0003031551,0.00003946039,0.0002838107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00957463,"threshold_uncertainty_score":0.05063611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02014336714121851,"score_gpt":0.259152892376774,"score_spread":0.2390095252355555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}