{"id":"W4401977743","doi":"10.26685/urncst.602","title":"Where Do We Stand in Targeted Therapy Against BRCA1/2 Deficient Cancers?","year":2024,"lang":"en","type":"article","venue":"Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Targeted therapy; Oncology; Medicine; Cancer research; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003433482,0.0005492393,0.002151786,0.001988138,0.0005030778,0.002923819,0.001128961,0.003461454,0.006787466],"category_scores_gemma":[0.005933566,0.0002400214,0.001343382,0.002200576,0.0008748219,0.006564467,0.0008450179,0.003149878,0.002224193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001156171,"about_ca_system_score_gemma":0.003049491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001377087,"about_ca_topic_score_gemma":0.003266847,"domain_scores_codex":[0.9991084,0.0002900338,0.0001752234,0.0001128212,0.0002396414,0.00007396282],"domain_scores_gemma":[0.9949489,0.002855496,0.0007310816,0.00006103591,0.0010899,0.0003136628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006618586,0.0001012317,0.0008010239,0.06248263,0.0004234219,0.0005900075,0.0002319506,0.0002565843,0.001339983,0.00597767,0.1195664,0.8075672],"study_design_scores_gemma":[0.0001815658,0.0003815131,0.001581616,0.06491809,0.0009366762,0.00143449,0.0008010166,0.0001984233,0.0004905771,0.01007504,0.9189349,0.00006622601],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003412375,0.9710469,0.0001972516,0.02432441,0.002401196,0.00002115512,0.0001149006,0.0000194052,0.001533496],"genre_scores_gemma":[0.003449637,0.9776043,0.0005512756,0.01334684,0.003731735,0.00004537185,0.0001205958,0.00001230432,0.001138067],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006787466,"threshold_uncertainty_score":0.02270639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04047183101028173,"score_gpt":0.4060271672163106,"score_spread":0.3655553362060289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}