{"id":"W4401978856","doi":"10.1158/1078-0432.ccr-24-1611","title":"Update on Pediatric Cancer Surveillance Recommendations for Patients with Neurofibromatosis Type 1, Noonan Syndrome, CBL Syndrome, Costello Syndrome, and Related RASopathies","year":2024,"lang":"en","type":"review","venue":"Clinical Cancer Research","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Manchester Biomedical Research Centre; National Institute for Health and Care Research; American Lebanese Syrian Associated Charities; National Cancer Institute; National Institutes of Health; Alexion Pharmaceuticals","keywords":"Costello syndrome; Noonan syndrome; Medicine; Neurofibromatosis; Genetic counseling; Cancer; Pediatrics; Population; Internal medicine; Pathology; Genetics; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002713749,0.0005339218,0.0009928618,0.002685065,0.0002834896,0.0009466188,0.001444167,0.001785832,0.005245538],"category_scores_gemma":[0.006891119,0.0003395221,0.001224893,0.002375994,0.0002492839,0.001222949,0.0008347968,0.002208986,0.002909449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001578385,"about_ca_system_score_gemma":0.003952634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005783451,"about_ca_topic_score_gemma":0.012797,"domain_scores_codex":[0.9988114,0.0003880853,0.0002777356,0.00007879658,0.0003757572,0.00006817773],"domain_scores_gemma":[0.9960093,0.001145305,0.0005487881,0.00006567736,0.00199955,0.0002312564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004427132,0.00003053976,0.0006187376,0.006744775,0.00008298427,0.0001391209,0.00006849131,0.0001996161,0.0002293634,0.001708363,0.4392081,0.5509256],"study_design_scores_gemma":[0.00002331114,0.00003009433,0.001299203,0.007016,0.0001397905,0.0004601833,0.00004309765,0.00005181305,0.00009157857,0.0004749867,0.9903584,0.00001155688],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006256666,0.9412208,0.001403144,0.03083378,0.008007004,0.0002106756,0.002682193,0.0002280335,0.01478858],"genre_scores_gemma":[0.002169068,0.9665105,0.004415219,0.01427442,0.002757678,0.0002644343,0.004348749,0.00003329256,0.00522661],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005783451,"threshold_uncertainty_score":0.01754808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1064757217592318,"score_gpt":0.4623505615400932,"score_spread":0.3558748397808613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}