{"id":"W4401978856","doi":"10.1158/1078-0432.ccr-24-1611","title":"Update on Pediatric Cancer Surveillance Recommendations for Patients with Neurofibromatosis Type 1, Noonan Syndrome, CBL Syndrome, Costello Syndrome, and Related RASopathies","year":2024,"lang":"en","type":"review","venue":"Clinical Cancer Research","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Manchester Biomedical Research Centre; National Institute for Health and Care Research; American Lebanese Syrian Associated Charities; National Cancer Institute; National Institutes of Health; Alexion Pharmaceuticals","keywords":"Costello syndrome; Noonan syndrome; Medicine; Neurofibromatosis; Genetic counseling; Cancer; Pediatrics; Population; Internal medicine; Pathology; Genetics; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001663673,0.0006688011,0.001622176,0.0003697595,0.000308259,0.0001727417,0.000743977,0.0007475804,0.0001087336],"category_scores_gemma":[0.00117922,0.0005114339,0.0003709356,0.001375802,0.0004426734,0.00001807678,0.0006984802,0.001345812,0.000121727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001571421,"about_ca_system_score_gemma":0.001319039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008530558,"about_ca_topic_score_gemma":0.00005831542,"domain_scores_codex":[0.9944717,0.0009286884,0.001309321,0.00180819,0.0006166001,0.0008654888],"domain_scores_gemma":[0.9966046,0.0008965174,0.000451545,0.001031241,0.0006346259,0.000381433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002168917,0.001624561,0.02783261,0.06475295,0.004005583,0.0007423043,0.00001898672,0.00001029188,0.000002895076,0.0005818603,0.3053882,0.5928708],"study_design_scores_gemma":[0.001302779,0.005162142,0.002868348,0.006845772,0.0008248746,0.0001865996,0.000003106483,0.000002630729,0.00001096768,0.0001039705,0.9817635,0.0009252492],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01399623,0.9757181,0.000001944592,0.0004301809,0.001270062,0.003309273,0.005185776,0.0000515967,0.00003679561],"genre_scores_gemma":[0.008646379,0.9841668,0.000106202,0.00009008989,0.0001968194,0.002189413,0.003381106,0.0002472019,0.0009759772],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6763754,"threshold_uncertainty_score":0.9997337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1064757217592318,"score_gpt":0.4623505615400932,"score_spread":0.3558748397808613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}