{"id":"W4401981346","doi":"10.20944/preprints202408.0650.v2","title":"Rethinking Cancer Initiation, Promotion, and Progression: Senescence, Endopolyploidy and Meiosis as Players in a Stress-Induced Regenerative Cell Cycle","year":2024,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Georgetown Hospital","funders":"","keywords":"Senescence; Biology; Promotion (chess); Meiosis; Cell biology; Cell cycle; Cancer; Genetics; Gene; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002742872,0.0005850964,0.0009231283,0.001405204,0.0009824553,0.004086136,0.0007159362,0.001712152,0.001868457],"category_scores_gemma":[0.002950543,0.0003214852,0.0005951226,0.0009415936,0.008016107,0.008092019,0.002650657,0.004198179,0.000638375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001757329,"about_ca_system_score_gemma":0.002141939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001591197,"about_ca_topic_score_gemma":0.001507446,"domain_scores_codex":[0.9991239,0.0002778768,0.00004638856,0.0001627627,0.000301953,0.00008727644],"domain_scores_gemma":[0.9985974,0.000545214,0.0001610294,0.0002292378,0.0002232829,0.0002436562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0004852022,0.00005955936,0.003692569,0.001381762,0.00007834315,0.0006140496,0.004073419,0.002184231,0.02822395,0.8075785,0.01505179,0.1365767],"study_design_scores_gemma":[0.0000369372,0.0001104624,0.005778595,0.0005529408,0.00004541027,0.0005719334,0.001727799,0.002158903,0.006711473,0.7895103,0.1926872,0.0001079563],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1454542,0.551448,0.09510353,0.1394412,0.01690777,0.00009742758,0.0005844493,0.0009605347,0.05000282],"genre_scores_gemma":[0.6306576,0.2587555,0.04641342,0.01585435,0.01449759,0.0001904422,0.0005443728,0.0007192871,0.03236749],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004086136,"threshold_uncertainty_score":0.01450586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07771181119796257,"score_gpt":0.3703192599586622,"score_spread":0.2926074487606997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}