{"id":"W4401990667","doi":"10.1021/acs.joc.4c01556","title":"Diastereoselective Synthesis of Phosphinyl Peptides via Rh-Catalyzed 1,4-Addition in Coparticipation of a <i>P</i>-Chiral Moiety and Difluorphos","year":2024,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Moiety; Catalysis; Chemistry; Stereochemistry; Combinatorial chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002155177,0.0005910539,0.0002752637,0.0001790968,0.0001786654,0.0002349789,0.0003281948,0.0003134508,0.001168085],"category_scores_gemma":[0.0001519103,0.0002132063,0.0001957299,0.0001877933,0.000196852,0.0003484112,0.0003449221,0.0006184389,0.0006779158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002289895,"about_ca_system_score_gemma":0.0003620675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002512486,"about_ca_topic_score_gemma":0.0004612854,"domain_scores_codex":[0.9998634,0.0000229878,0.00001392787,0.00003419017,0.00002720875,0.00003833498],"domain_scores_gemma":[0.9999413,0.000007997533,0.00001986375,0.000007507831,0.000008139017,0.00001516123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008441255,0.00002759962,0.00007600698,0.0000937958,0.000007674545,0.0003317203,0.00004834358,0.0003576876,0.9927297,0.0008197455,0.0001272847,0.005296012],"study_design_scores_gemma":[0.00001107506,0.0001028704,0.000175957,0.000003117727,0.000005748505,0.0002032495,0.000007918326,0.0003101804,0.9971331,0.00007807621,0.00196409,0.00000470231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9475369,0.001487572,0.03492596,0.0002473084,0.0001010307,0.0001655804,0.0009659451,0.0002904441,0.01427937],"genre_scores_gemma":[0.9783639,0.001115228,0.01536795,0.00006720843,0.00001917918,0.00005795043,0.0004822201,0.00006125071,0.004465135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001168085,"threshold_uncertainty_score":0.003907561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004285122447441782,"score_gpt":0.2124782272532011,"score_spread":0.2081931048057593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}