{"id":"W4402001825","doi":"10.1093/cid/ciae423","title":"Efficacy and Safety of Long-Acting Subcutaneous Lenacapavir in Heavily Treatment-Experienced People with Multidrug-Resistant HIV-1: Week 104 Results of a Phase 2/3 Trial","year":2024,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Maple Leaf Medical Clinic","funders":"Gilead Sciences","keywords":"Medicine; Drug; Human immunodeficiency virus (HIV); Clinical trial; Drug trial; Family medicine; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002545272,0.0009931362,0.001330306,0.0002340318,0.0005267878,0.0010549,0.0006668058,0.001370036,0.003567089],"category_scores_gemma":[0.00217991,0.0004303811,0.001465712,0.0002439296,0.0006040001,0.0008366183,0.0003493019,0.002900927,0.0007605082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006433035,"about_ca_system_score_gemma":0.0009691612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006718449,"about_ca_topic_score_gemma":0.001343249,"domain_scores_codex":[0.9991421,0.0005123753,0.00005033708,0.00009983703,0.00007414533,0.000121166],"domain_scores_gemma":[0.9985074,0.0003171997,0.0003883066,0.0001449882,0.00014377,0.0004982586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8229718,0.04389765,0.01525307,0.0007227954,0.002026651,0.0002230425,0.000418042,0.001355513,0.01894701,0.000129477,0.003578495,0.09047638],"study_design_scores_gemma":[0.6435406,0.3159142,0.0345296,0.0001117701,0.0006864105,0.0002224998,0.00008920337,0.001013711,0.002048922,0.000168297,0.001628825,0.00004595204],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954283,0.0009560745,0.0002545165,0.0003407071,0.00004935468,0.001254942,0.0004601062,0.00006076272,0.001195224],"genre_scores_gemma":[0.9936228,0.0006287667,0.001090511,0.0006078649,0.00008764292,0.001879362,0.0008666006,0.00002268367,0.001193779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003567089,"threshold_uncertainty_score":0.01346081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03465481463144065,"score_gpt":0.3693012088373128,"score_spread":0.3346463942058722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}