{"id":"W4402003786","doi":"10.1002/advs.202405432","title":"A Novel Antigen Design Strategy to Isolate Single‐Domain Antibodies that Target Human Nav1.7 and Reduce Pain in Animal Models","year":2024,"lang":"en","type":"article","venue":"Advanced Science","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Antibody; Antigen; Computer science; Computational biology; Medicine; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001609442,0.0004343015,0.0002214533,0.0002396128,0.0001173025,0.0002364648,0.0002847152,0.0004059418,0.000785004],"category_scores_gemma":[0.00009152262,0.0001585119,0.0002425282,0.0001044589,0.0001228071,0.0001831296,0.0001937594,0.0005489604,0.000345429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002430409,"about_ca_system_score_gemma":0.0002166107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002892737,"about_ca_topic_score_gemma":0.0004104138,"domain_scores_codex":[0.9998879,0.00001506935,0.000006960037,0.00002476234,0.00003008797,0.00003531148],"domain_scores_gemma":[0.9999552,0.000005722869,0.00001245629,0.00000418536,0.0000113661,0.00001115832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003077724,0.00007632195,0.00004858819,0.00002457506,0.000004716487,0.00002749103,0.000004358415,0.000215211,0.9969062,0.0001692708,0.0000641001,0.00242832],"study_design_scores_gemma":[0.00006780584,0.001163672,0.0006399889,0.000006574283,0.00002327099,0.0002922718,0.000008806882,0.003004182,0.9908681,0.000119645,0.003797925,0.000007714977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9042623,0.001725048,0.08957712,0.0002455109,0.0001538379,0.0004517901,0.0002655408,0.0002215691,0.003097316],"genre_scores_gemma":[0.9381307,0.0009247615,0.05681138,0.0003575474,0.00003372953,0.0002186926,0.0003671084,0.00003324285,0.00312269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000785004,"threshold_uncertainty_score":0.002626061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.104870189652376,"score_gpt":0.3744873020222492,"score_spread":0.2696171123698732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}