{"id":"W4402003786","doi":"10.1002/advs.202405432","title":"A Novel Antigen Design Strategy to Isolate Single‐Domain Antibodies that Target Human Nav1.7 and Reduce Pain in Animal Models","year":2024,"lang":"en","type":"article","venue":"Advanced Science","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Antibody; Antigen; Computer science; Computational biology; Medicine; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00165529,0.0002157479,0.0002960824,0.0004223619,0.0002790703,0.0001699197,0.0002620168,0.00005193433,0.00002646904],"category_scores_gemma":[0.0001139641,0.0001730462,0.00004402722,0.001053304,0.0005952661,0.0007027552,0.0001790676,0.000279088,0.00001365181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000106311,"about_ca_system_score_gemma":0.000262962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001406606,"about_ca_topic_score_gemma":0.00003514851,"domain_scores_codex":[0.9975945,0.00006210752,0.0002518033,0.0007449361,0.0006212607,0.0007253809],"domain_scores_gemma":[0.9991726,0.0001631687,0.00002860558,0.0002191104,0.00009098752,0.0003255694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002346027,0.00008623244,0.0006580742,0.000093741,0.000009131578,0.0001793861,0.0008700587,0.001418394,0.9809937,0.003730994,0.00006105569,0.01166465],"study_design_scores_gemma":[0.003016439,0.01438287,0.06660224,0.004385414,0.00003572196,0.0008895451,0.003996312,0.3139756,0.5187818,0.0640406,0.007748334,0.002145086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9621058,0.002123894,0.03178265,0.001438871,0.0000699181,0.0005417526,0.00001972911,0.00006775447,0.001849633],"genre_scores_gemma":[0.9453478,0.000154933,0.0534564,0.0002538766,0.00005182501,0.00001946459,0.000004485559,0.00001977717,0.0006914558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4622118,"threshold_uncertainty_score":0.7056618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.104870189652376,"score_gpt":0.3744873020222492,"score_spread":0.2696171123698732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}