{"id":"W4402005937","doi":"10.1242/jcs.262035","title":"AP-1 contributes to endosomal targeting of the ubiquitin ligase RNF13 via a secondary and novel non-canonical binding motif","year":2024,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; PROTEO; Université du Québec à Montréal","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Endosome; Signal transducing adaptor protein; Cell biology; Ubiquitin ligase; Clathrin; Ubiquitin; Protein Sorting Signals; Protein targeting; Transport protein; Plasma protein binding; Golgi apparatus; Biochemistry; Peptide sequence; Signal transduction; Endocytosis; Membrane protein; Endoplasmic reticulum; Receptor; Signal peptide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007887041,0.0000738322,0.0001158148,0.00007703031,0.00009212268,0.00005145208,0.0002453274,0.00004951811,0.00001038747],"category_scores_gemma":[0.00006735897,0.00005029628,0.00009031761,0.00024309,0.0001954871,0.00001423286,0.00008213337,0.0001468651,8.252915e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001637904,"about_ca_system_score_gemma":0.0003401658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004722137,"about_ca_topic_score_gemma":0.000005102124,"domain_scores_codex":[0.999164,0.00001216588,0.0002782523,0.0001582632,0.0002164053,0.0001709354],"domain_scores_gemma":[0.9995738,0.00002095251,0.0001049531,0.0000907443,0.0001117908,0.00009778485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000300013,0.00002044564,0.0008477363,0.00003047094,0.000007409696,0.000006829271,0.00009548692,0.00002665761,0.9983695,0.00003178097,0.00003866625,0.0004949977],"study_design_scores_gemma":[0.0002415591,0.0001538563,0.003864396,0.00008041059,0.00001862981,0.00004935604,0.00007803016,0.000398963,0.9908569,0.00002797794,0.004171253,0.00005867302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9688239,0.000907163,0.02924397,0.0002922271,0.000322459,0.00007198203,0.00000840388,0.000001406541,0.0003285246],"genre_scores_gemma":[0.9989161,0.00004614044,0.0007475077,0.00007273478,0.0001129673,6.269983e-7,0.000004393399,0.000005452486,0.00009404954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03009226,"threshold_uncertainty_score":0.2051023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0048078033840372,"score_gpt":0.2204549415985234,"score_spread":0.2156471382144862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}