{"id":"W4402005937","doi":"10.1242/jcs.262035","title":"AP-1 contributes to endosomal targeting of the ubiquitin ligase RNF13 via a secondary and novel non-canonical binding motif","year":2024,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; PROTEO; Université du Québec à Montréal","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Endosome; Signal transducing adaptor protein; Cell biology; Ubiquitin ligase; Clathrin; Ubiquitin; Protein Sorting Signals; Protein targeting; Transport protein; Plasma protein binding; Golgi apparatus; Biochemistry; Peptide sequence; Signal transduction; Endocytosis; Membrane protein; Endoplasmic reticulum; Receptor; Signal peptide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001576278,0.0002633689,0.0001779851,0.0001218119,0.0001639491,0.0002981184,0.0002652713,0.0002926309,0.001013878],"category_scores_gemma":[0.000165481,0.00009462886,0.0002541915,0.0001129076,0.0002248949,0.0001666491,0.000273422,0.0003648936,0.0004181839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005575901,"about_ca_system_score_gemma":0.0002640951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000889239,"about_ca_topic_score_gemma":0.00090652,"domain_scores_codex":[0.999876,0.00002431117,0.00001236234,0.00002712231,0.00003710929,0.00002306004],"domain_scores_gemma":[0.999907,0.00001369714,0.00002355858,0.00001242077,0.00001592825,0.00002729961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008972951,0.000007445073,0.000299087,0.00001898171,0.000004749353,0.0001665853,0.000005361713,0.0001124587,0.9979837,0.0001927391,0.00001333624,0.001105835],"study_design_scores_gemma":[0.000005664122,0.00004609896,0.00250187,0.000002147891,0.000008207036,0.0007403976,0.00001205861,0.001069018,0.9939675,0.00005210339,0.00159152,0.000003336021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926701,0.0004433391,0.005869333,0.00005382906,0.00001362362,0.00001145287,0.0000893008,0.00004888327,0.0008002105],"genre_scores_gemma":[0.994826,0.0002308876,0.003261912,0.00002586648,0.000003908515,0.000008235233,0.000216175,0.00001457152,0.001412416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001013878,"threshold_uncertainty_score":0.004045606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0048078033840372,"score_gpt":0.2204549415985234,"score_spread":0.2156471382144862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}