{"id":"W4402007941","doi":"10.31083/j.jin2308158","title":"A Preliminary Finding: N-butyl-phthalide Plays a Neuroprotective Role by Blocking the TLR4/HMGB1 Pathway and Improves Mild Cognitive Impairment Induced by Acute Cerebral Infarction","year":2024,"lang":"en","type":"article","venue":"Journal of Integrative Neuroscience","topic":"Neurological Disease Mechanisms and Treatments","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Guangxi Zhuang Autonomous Region Health and Family Planning Commission","keywords":"Phthalide; Neuroprotection; Blocking (statistics); HMGB1; Cognitive impairment; Cognition; Infarction; Pharmacology; Medicine; Neuroscience; Chemistry; Psychology; Internal medicine; Computer science; Receptor; Myocardial infarction; Organic chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003360509,0.0007535144,0.0005780465,0.0002892395,0.0002449898,0.0002120541,0.0004390774,0.0003917351,0.007080772],"category_scores_gemma":[0.0002409082,0.0001140541,0.0006679717,0.0001663583,0.0003900039,0.0003717354,0.00025688,0.000984105,0.0008114084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000104307,"about_ca_system_score_gemma":0.0005164278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004661061,"about_ca_topic_score_gemma":0.0007010204,"domain_scores_codex":[0.9999233,0.00001295936,0.00001276997,0.00001720703,0.00001523294,0.00001851839],"domain_scores_gemma":[0.9998538,0.00002065575,0.00002447659,0.00001817312,0.00004327944,0.00003957891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01998627,0.006406261,0.002632206,0.002599969,0.0003744231,0.0009061645,0.0001314226,0.0002030677,0.9039586,0.0006015792,0.002980646,0.05921939],"study_design_scores_gemma":[0.004062525,0.06621337,0.0330927,0.0001681519,0.001084328,0.002401878,0.0001821528,0.0007454011,0.8724822,0.0007956501,0.01873075,0.00004092323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736612,0.01045947,0.005646205,0.001876744,0.0006788222,0.0006281328,0.001387627,0.0002347048,0.005427194],"genre_scores_gemma":[0.971337,0.009699437,0.005653883,0.0009741895,0.0003271572,0.000663792,0.00161762,0.0000362307,0.009690732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007080772,"threshold_uncertainty_score":0.02368754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0254931465797586,"score_gpt":0.2847557956025736,"score_spread":0.259262649022815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}