{"id":"W4402022264","doi":"10.1016/j.exphem.2024.104577","title":"2020 – PRECISE SINGLE-CELL TRANSCRIPTOMIC MAPPING OF NORMAL AND LEUKEMIC CELL STATES REVEALS UNCONVENTIONAL LINEAGE PRIMING IN ACUTE MYELOID LEUKEMIA","year":2024,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; Princess Margaret Cancer Centre; Health Sciences Centre; University Health Network","funders":"","keywords":"Myeloid leukemia; Priming (agriculture); Lineage (genetic); Myeloid; Cell; Transcriptome; Leukemia; Biology; Cancer research; Computational biology; Cell biology; Immunology; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003084814,0.0003256788,0.0007528518,0.0004446577,0.00005711189,0.00003105757,0.0001825255,0.0002518581,0.0004847513],"category_scores_gemma":[0.0000166951,0.0003188604,0.000162465,0.0003876114,0.0003117746,0.0002245638,0.0001700927,0.0005915989,0.00005379386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001131542,"about_ca_system_score_gemma":0.0005324492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000975623,"about_ca_topic_score_gemma":0.00000732329,"domain_scores_codex":[0.9974751,0.0001228229,0.0008352674,0.0006392749,0.0003327696,0.0005946949],"domain_scores_gemma":[0.9991331,0.0002384825,0.0001089343,0.0002644816,0.00004809284,0.0002069616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005499461,0.0003058082,0.003076505,0.001524162,0.0001061666,0.001059883,0.003869004,0.00001007718,0.9865149,0.000435599,0.00224232,0.0003056024],"study_design_scores_gemma":[0.00363552,0.0005180294,0.0005905284,0.0006000375,0.00005967416,0.001428704,0.002597935,0.003832177,0.9857457,0.00007882118,0.0006526842,0.0002601425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680281,0.02838048,0.0002204819,0.0002134289,0.000287256,0.0007137628,0.00004025783,0.00008556735,0.002030658],"genre_scores_gemma":[0.9936899,0.0004891309,0.003404233,0.0001270829,0.00008126923,0.0000855723,0.0001557956,0.00006808992,0.001898946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02789135,"threshold_uncertainty_score":0.9999263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01907441548879266,"score_gpt":0.2893628071163101,"score_spread":0.2702883916275175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}