{"id":"W4402022264","doi":"10.1016/j.exphem.2024.104577","title":"2020 – PRECISE SINGLE-CELL TRANSCRIPTOMIC MAPPING OF NORMAL AND LEUKEMIC CELL STATES REVEALS UNCONVENTIONAL LINEAGE PRIMING IN ACUTE MYELOID LEUKEMIA","year":2024,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; Princess Margaret Cancer Centre; Health Sciences Centre; University Health Network","funders":"","keywords":"Myeloid leukemia; Priming (agriculture); Lineage (genetic); Myeloid; Cell; Transcriptome; Leukemia; Biology; Cancer research; Computational biology; Cell biology; Immunology; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001454884,0.0001499505,0.0001852537,0.000225287,0.0001877342,0.0004961939,0.0001615455,0.0002145862,0.001699926],"category_scores_gemma":[0.0001962307,0.0001923995,0.0001419107,0.0001657556,0.0002738352,0.0002374878,0.0003252823,0.0003467204,0.0005402955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002116223,"about_ca_system_score_gemma":0.0001433591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003917743,"about_ca_topic_score_gemma":0.001311113,"domain_scores_codex":[0.999885,0.00001484904,0.00000771689,0.00003767555,0.00002801686,0.00002672144],"domain_scores_gemma":[0.9998972,0.00003550317,0.00002017956,0.0000191905,0.00001138691,0.00001647864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005487994,0.000003240751,0.0002014745,0.000005530654,9.231946e-7,0.00001586758,0.0000141686,0.00004217159,0.9985707,0.0002066404,0.00002316879,0.0008612592],"study_design_scores_gemma":[0.000009284653,0.00009097933,0.01921513,0.000004073582,0.000009964429,0.0002549487,0.0001022727,0.003205301,0.9733999,0.0004509641,0.003248206,0.000008925005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811524,0.0004963063,0.01434927,0.00008830466,0.00002813596,0.00002829456,0.001118019,0.0001606738,0.002578497],"genre_scores_gemma":[0.9895866,0.0002434671,0.006632627,0.00008434791,0.00001221306,0.00003626659,0.001025014,0.0001000301,0.002279394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001699926,"threshold_uncertainty_score":0.00568682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01907441548879266,"score_gpt":0.2893628071163101,"score_spread":0.2702883916275175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}