{"id":"W4402023070","doi":"10.1016/j.exphem.2024.104480","title":"3160 – MYCN IS AN ESSENTIAL IMMATURE T-ALL ONCOGENIC DRIVER MARKED BY BROAD H3K4ME3","year":2024,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"","keywords":"H3K4me3; Biology; Genetics; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00005779505,0.000258321,0.0002476903,0.00004642972,0.00007138665,0.00006846376,0.000251872,0.0003261047,0.0006209655],"category_scores_gemma":[0.000008787589,0.0002628059,0.0001605936,0.00006790571,0.0001402758,0.000008990068,0.0002029211,0.0001383316,0.0001293344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004829075,"about_ca_system_score_gemma":0.00009507794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006466002,"about_ca_topic_score_gemma":0.00002605401,"domain_scores_codex":[0.9985629,0.00004587536,0.0002483398,0.000651336,0.000117072,0.0003745132],"domain_scores_gemma":[0.9993446,0.00001818131,0.00004487104,0.0004051513,0.00002559832,0.0001615704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002106199,0.0002134987,0.000130486,0.00002995132,0.00015584,0.00007064654,0.0004421475,0.000001578956,0.8250402,0.003032697,0.1701068,0.0005654758],"study_design_scores_gemma":[0.0004444836,0.0002998728,0.0000228509,0.00001139027,0.00002460587,0.0002112479,0.0002209169,0.0001822083,0.7965307,0.00009537688,0.2016842,0.0002721587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9131263,0.08214816,0.0004120276,0.000360028,0.001313284,0.0002582532,0.0002219699,0.00005819489,0.002101721],"genre_scores_gemma":[0.9954892,0.0004462534,0.0004129525,0.001146903,0.0003687782,0.00005427243,0.0007138643,0.00005759019,0.001310139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08236289,"threshold_uncertainty_score":0.9999824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006158157222580457,"score_gpt":0.2834567691311342,"score_spread":0.2772986119085538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}