{"id":"W4402023479","doi":"10.1016/j.jhep.2024.08.010","title":"Sequential Peg-IFN after bepirovirsen may reduce post-treatment relapse in chronic hepatitis B","year":2024,"lang":"en","type":"article","venue":"Journal of Hepatology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"NIHR Newcastle Biomedical Research Centre; Cumming School of Medicine, University of Calgary; Chugai Pharmaceutical; University of California, Davis; Ruijin Hospital; Instituto de Investigación Marqués de Valdecilla; Uniwersytet Śląski w Katowicach; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; Pusan National University Hospital; Nagoya City University; Shanghai Jiao Tong University; Newcastle upon Tyne Hospitals NHS Foundation Trust; Zhejiang Shuren University; Korea University; Pusan National University; Novo Nordisk; National Institute for Health and Care Research; Gilead Sciences; GlaxoSmithKline España; Yuhan; Kaken Pharmaceutical; Kowa Company; Alnylam Pharmaceuticals; Wayne State University; Otsuka Pharmaceutical; China Scholarship Council; Università degli Studi di Milano; GlaxoSmithKline; AstraZeneca; Bristol-Myers Squibb","keywords":"HBsAg; Pegylated interferon; Medicine; Virology; PEG ratio; Hepatitis B virus; Chronic hepatitis; Oligonucleotide; Hepatology; Hepatitis B; Interferon; Immunology; Virus; Internal medicine; Biology; DNA; Ribavirin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002983229,0.000260414,0.0008264171,0.0005781761,0.00004381246,0.00002731543,0.0001057769,0.0002024945,0.000586936],"category_scores_gemma":[0.0001949921,0.0001996314,0.0003144993,0.0002564206,0.0001698674,0.0001845164,0.00006970632,0.0005177897,0.000241064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002492143,"about_ca_system_score_gemma":0.001449034,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.007795579,"about_ca_topic_score_gemma":0.03204153,"domain_scores_codex":[0.9978688,0.0001930778,0.000880671,0.0002905035,0.0003114865,0.000455417],"domain_scores_gemma":[0.9989982,0.0001571484,0.0001711408,0.0002423597,0.0002567904,0.0001743071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009329084,0.0003299839,0.9158213,0.0002782622,0.0009088102,0.04761725,0.002176851,0.000009352374,0.007788653,0.0004240204,0.007501835,0.01621082],"study_design_scores_gemma":[0.007360422,0.0147967,0.4996449,0.002411352,0.001718338,0.03839348,0.0002274109,0.0007633575,0.01280033,0.001419582,0.4196174,0.000846663],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9556946,0.02289463,0.00002402738,0.01814706,0.001618879,0.0002579607,0.0000262981,0.00003562604,0.001300884],"genre_scores_gemma":[0.9907067,0.006104422,0.0005565109,0.0005634752,0.000813117,0.00003076548,0.00000690507,0.00004563678,0.001172423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4161763,"threshold_uncertainty_score":0.9988116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02193149720854192,"score_gpt":0.3230608436530161,"score_spread":0.3011293464444742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}