{"id":"W4402023479","doi":"10.1016/j.jhep.2024.08.010","title":"Sequential Peg-IFN after bepirovirsen may reduce post-treatment relapse in chronic hepatitis B","year":2024,"lang":"en","type":"article","venue":"Journal of Hepatology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"NIHR Newcastle Biomedical Research Centre; Cumming School of Medicine, University of Calgary; Chugai Pharmaceutical; University of California, Davis; Ruijin Hospital; Instituto de Investigación Marqués de Valdecilla; Uniwersytet Śląski w Katowicach; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; Pusan National University Hospital; Nagoya City University; Shanghai Jiao Tong University; Newcastle upon Tyne Hospitals NHS Foundation Trust; Zhejiang Shuren University; Korea University; Pusan National University; Novo Nordisk; National Institute for Health and Care Research; Gilead Sciences; GlaxoSmithKline España; Yuhan; Kaken Pharmaceutical; Kowa Company; Alnylam Pharmaceuticals; Wayne State University; Otsuka Pharmaceutical; China Scholarship Council; Università degli Studi di Milano; GlaxoSmithKline; AstraZeneca; Bristol-Myers Squibb","keywords":"HBsAg; Pegylated interferon; Medicine; Virology; PEG ratio; Hepatitis B virus; Chronic hepatitis; Oligonucleotide; Hepatology; Hepatitis B; Interferon; Immunology; Virus; Internal medicine; Biology; DNA; Ribavirin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000853253,0.0005387163,0.001224314,0.0001883639,0.0001927346,0.0003210301,0.0003649103,0.0006024152,0.002637787],"category_scores_gemma":[0.001156509,0.0002064804,0.0007779285,0.0001780839,0.0002362279,0.0002785316,0.0002089187,0.0008328191,0.0002615569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003242645,"about_ca_system_score_gemma":0.0003972767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007556461,"about_ca_topic_score_gemma":0.001400131,"domain_scores_codex":[0.999658,0.0001850572,0.00002766499,0.00004487414,0.00003306774,0.00005136962],"domain_scores_gemma":[0.9995372,0.0001471156,0.0001586612,0.00002945892,0.00002137202,0.0001062143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7049599,0.0167083,0.006259882,0.001074209,0.001268447,0.00007595974,0.0001581628,0.001036177,0.009493348,0.0001110488,0.001065968,0.2577886],"study_design_scores_gemma":[0.3163763,0.5853747,0.08064222,0.0003458723,0.002004839,0.0003314264,0.0001613808,0.003743601,0.007231821,0.0003634426,0.003389359,0.00003507586],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958497,0.002839844,0.0001816579,0.0001805703,0.00005289482,0.0001697916,0.00005710726,0.00003228124,0.0006360956],"genre_scores_gemma":[0.9979203,0.0008149725,0.0003272098,0.0001440891,0.00004735545,0.0001568129,0.00007672304,0.000004154635,0.0005084839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002637787,"threshold_uncertainty_score":0.008824229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02193149720854192,"score_gpt":0.3230608436530161,"score_spread":0.3011293464444742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}