{"id":"W4402023716","doi":"10.1016/j.exphem.2024.104402","title":"3080 – HUMANIZED DRAGA MOUSE MODEL RECAPITULATES HUMAN T-CELL DIFFERENTIATION IN THE MOUSE THYMUS WITH HLA-MATCHED DONORS","year":2024,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Terry Fox Research Institute; University of British Columbia","funders":"","keywords":"Humanized mouse; Human leukocyte antigen; Cell biology; Immunology; Biology; Cancer research; Molecular biology; Antigen; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004359309,0.0008350926,0.0004100808,0.001489909,0.0005946511,0.0007332133,0.0006112465,0.0009546875,0.01065612],"category_scores_gemma":[0.000159861,0.0004167248,0.0005257146,0.0004811927,0.000852023,0.0005009706,0.000462135,0.001900098,0.003590486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004270345,"about_ca_system_score_gemma":0.0003235848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004891493,"about_ca_topic_score_gemma":0.001007794,"domain_scores_codex":[0.9994726,0.00007679579,0.00006354523,0.0001744345,0.0001180713,0.00009465784],"domain_scores_gemma":[0.9996909,0.00002668634,0.00009511872,0.00006265206,0.0000194935,0.0001051074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006441831,0.0004318174,0.0004448093,0.00007082299,0.00001772609,0.0006575431,0.00006550668,0.0001369451,0.9930515,0.001612082,0.0006206399,0.00224623],"study_design_scores_gemma":[0.0008118041,0.00257552,0.01111736,0.000124665,0.0002147885,0.01282,0.0003092849,0.002590423,0.8967872,0.001120128,0.0714621,0.00006679995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731468,0.001590939,0.01041599,0.0003617334,0.0004290506,0.0003647063,0.004589929,0.0007217312,0.008379262],"genre_scores_gemma":[0.9530004,0.001541833,0.009905794,0.0003538219,0.0001328708,0.0007827732,0.004393742,0.0003542148,0.02953447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01065612,"threshold_uncertainty_score":0.03564829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01106912298292316,"score_gpt":0.2757336013600654,"score_spread":0.2646644783771422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}