{"id":"W4402023946","doi":"10.1016/j.exphem.2024.104484","title":"3164 – IDENTIFICATION OF GENE REGULATORY NETWORKS ESSENTIAL FOR HEMATOPOIETIC PROGENITOR CELL AND T CELL EMERGENCE FROM HUMAN PLURIPOTENT STEM CELL VIA CRISPR SCREENS","year":2024,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Biomedical Ethics and Regulation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; University of British Columbia","funders":"","keywords":"Induced pluripotent stem cell; CRISPR; Progenitor cell; Identification (biology); Biology; Cell; Stem cell; Haematopoiesis; Gene; Cell biology; Hematopoietic stem cell; Computational biology; Genetics; Embryonic stem cell; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002048886,0.0002167366,0.0004205942,0.0001112898,0.000133278,0.00002000768,0.0001041836,0.0003810618,0.0001059058],"category_scores_gemma":[0.000001462042,0.0001935997,0.0001559106,0.000130629,0.0005221505,0.00006248881,0.0000714261,0.0001960014,0.00000900755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004253129,"about_ca_system_score_gemma":0.00005600091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005613469,"about_ca_topic_score_gemma":0.000003384187,"domain_scores_codex":[0.998111,0.00005767385,0.0007215704,0.0005406692,0.0002954562,0.0002736363],"domain_scores_gemma":[0.9991725,0.00006151431,0.0001966193,0.0003126225,0.00007812085,0.0001786404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009216888,0.0004287004,0.00005520835,0.0007562634,0.00004548227,0.0000233937,0.001393008,0.00000704901,0.9921677,0.00388796,0.0007896731,0.0003533551],"study_design_scores_gemma":[0.0009031082,0.0002568662,0.0002486657,0.0001098742,0.0001368255,0.00005766359,0.0007678201,0.01639674,0.9803101,0.0004679348,0.0001716827,0.0001727556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8783576,0.06478149,0.05365521,0.0004500121,0.001302824,0.001215073,0.00003774891,0.00009716273,0.0001028733],"genre_scores_gemma":[0.9974195,0.00006292866,0.001362144,0.00004611752,0.0002834754,0.0001068924,0.0002110396,0.00004598466,0.0004618979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1190619,"threshold_uncertainty_score":0.7894768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01398649714038907,"score_gpt":0.2984900270876421,"score_spread":0.284503529947253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}