{"id":"W4402023946","doi":"10.1016/j.exphem.2024.104484","title":"3164 – IDENTIFICATION OF GENE REGULATORY NETWORKS ESSENTIAL FOR HEMATOPOIETIC PROGENITOR CELL AND T CELL EMERGENCE FROM HUMAN PLURIPOTENT STEM CELL VIA CRISPR SCREENS","year":2024,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Biomedical Ethics and Regulation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; University of British Columbia","funders":"","keywords":"Induced pluripotent stem cell; CRISPR; Progenitor cell; Identification (biology); Biology; Cell; Stem cell; Haematopoiesis; Gene; Cell biology; Hematopoietic stem cell; Computational biology; Genetics; Embryonic stem cell; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003897073,0.0005854258,0.0003924048,0.0008193861,0.0004794313,0.0006484585,0.0006627435,0.0007294901,0.007716675],"category_scores_gemma":[0.0004713116,0.0004474249,0.0008172562,0.0003003012,0.0006033076,0.0001997634,0.0004445783,0.00121681,0.002174036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007448711,"about_ca_system_score_gemma":0.0008143989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001798688,"about_ca_topic_score_gemma":0.004192964,"domain_scores_codex":[0.9993412,0.00009307654,0.00006685919,0.0001486386,0.0002430545,0.0001072289],"domain_scores_gemma":[0.9994476,0.0002101905,0.0001317593,0.00006824114,0.0000457879,0.00009641475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001053525,0.00003045424,0.0001776927,0.00002880497,0.00001171537,0.0001212019,0.00001479072,0.000292584,0.9967638,0.000565846,0.0001801116,0.001707476],"study_design_scores_gemma":[0.00005123776,0.00009830995,0.002854313,0.000008016003,0.00003568655,0.000269947,0.00002288395,0.002679611,0.986938,0.0002159296,0.006812118,0.00001385496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8721471,0.0007569316,0.09216765,0.0006874696,0.0002448774,0.000520557,0.008070447,0.002454939,0.02295001],"genre_scores_gemma":[0.9546481,0.0003418839,0.0280439,0.0003843023,0.00002833378,0.0002039865,0.004681801,0.0006659024,0.0110018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007716675,"threshold_uncertainty_score":0.02581489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01398649714038907,"score_gpt":0.2984900270876421,"score_spread":0.284503529947253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}