{"id":"W4402024325","doi":"10.1016/j.exphem.2024.104450","title":"3129 – UTILIZING AN IPSC-DERIVED BONE MARROW-LIKE ORGANOID MODEL TO INVESTIGATE DRUG RESISTANCE MECHANISMS IN ACUTE MYELOID LEUKEMIA","year":2024,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Genome British Columbia","funders":"","keywords":"Organoid; Myeloid leukemia; Bone marrow; Drug resistance; Leukemia; Drug; Myeloid; Medicine; Bone marrow transplantation; Cancer research; Biology; Internal medicine; Pharmacology; Neuroscience; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004327562,0.0003231511,0.0002719056,0.0004895565,0.0003188353,0.0006431935,0.0003689778,0.0005945136,0.003635689],"category_scores_gemma":[0.000198288,0.0002068005,0.0004345702,0.0002696516,0.0003643203,0.0004582367,0.0003296269,0.001522796,0.001297648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003334428,"about_ca_system_score_gemma":0.0003684579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001044105,"about_ca_topic_score_gemma":0.001210335,"domain_scores_codex":[0.9997088,0.00004704328,0.00003698827,0.0000499671,0.000118423,0.00003875894],"domain_scores_gemma":[0.9998704,0.00002701158,0.00002753277,0.00002936265,0.00002381157,0.00002184312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001212194,0.0001014868,0.0002771919,0.00005688082,0.00001078812,0.0001321337,0.00004573502,0.0003031291,0.9937456,0.001193891,0.0002590028,0.003752982],"study_design_scores_gemma":[0.00005782737,0.0004218936,0.002593996,0.00002088558,0.00005100853,0.0006574517,0.0000764097,0.002662891,0.9733365,0.0004016497,0.01970989,0.000009696242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9193305,0.002979102,0.05038715,0.00080477,0.0003326123,0.0005860457,0.003842059,0.0005349788,0.02120268],"genre_scores_gemma":[0.9600021,0.001993098,0.01912862,0.0003387367,0.00002936834,0.0002980491,0.004186621,0.0001220292,0.01390127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003635689,"threshold_uncertainty_score":0.01216257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02732243321895482,"score_gpt":0.3240531566932399,"score_spread":0.2967307234742851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}