{"id":"W4402050881","doi":"10.1038/s41467-024-52009-x","title":"FAM72A degrades UNG2 through the GID/CTLH complex to promote mutagenic repair during antibody maturation","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Princess Margaret Cancer Centre; Sunnybrook Health Science Centre; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"CIHR Skin Research Training Centre; National Cancer Institute; Government of Canada; National Institutes of Health; Canadian Institutes of Health Research; Hospital for Sick Children; University of Toronto","keywords":"Antibody; DNA repair; Chemistry; Cell biology; Biology; Genetics; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001731673,0.0003180396,0.0001961832,0.0001727467,0.0002788457,0.0003662605,0.0002658442,0.0005602989,0.001995834],"category_scores_gemma":[0.0001452566,0.0001597265,0.0003279199,0.0001148131,0.0002398144,0.0003190496,0.0003080516,0.0004781256,0.0009202601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007689199,"about_ca_system_score_gemma":0.0002111621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000893072,"about_ca_topic_score_gemma":0.001105866,"domain_scores_codex":[0.9998645,0.0000105804,0.000007816075,0.00004330694,0.00003431381,0.00003940503],"domain_scores_gemma":[0.9999261,0.000005261624,0.00002215615,0.00001119923,0.00001371557,0.00002151925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001656863,0.00001279094,0.000914458,0.00004696308,0.00001244126,0.0002429831,0.00001388557,0.0001648398,0.9939697,0.0003894496,0.0005097018,0.003557271],"study_design_scores_gemma":[0.00001792137,0.0000687132,0.00387444,0.000004230147,0.000007669697,0.0004997592,0.00001359082,0.001703675,0.9856831,0.0001063192,0.008014769,0.00000582962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9744651,0.005249064,0.01335332,0.0008917288,0.0001547767,0.00003578902,0.0007382968,0.0007864032,0.004325488],"genre_scores_gemma":[0.9877555,0.0007390122,0.003892132,0.0001957489,0.00001656868,0.00001647397,0.0006663674,0.00003480168,0.006683449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001995834,"threshold_uncertainty_score":0.006676733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02201309840690045,"score_gpt":0.3340302925047073,"score_spread":0.3120171940978069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}